PMID: 9428498Jan 15, 1998Paper

Nerve lesions after therapy for childhood acute lymphoblastic leukemia

Cancer
A H Harila-SaariB M Lanning

Abstract

The objective of the current study was to use somatosensory evoked potentials (SEP) to detect signs of nerve lesions in the peripheral nerve and in the central nervous system (CNS) after 3 years of treatment for childhood acute lymphoblastic leukemia (ALL). The somatosensory potentials evoked by stimulation of the median nerve and posterior tibial nerve were recorded in 31 children with ALL after 3 years of therapy. All patients were examined clinically. The 14 standard risk patients had been treated with chemotherapy according to the Nordic regimen, and the 17 intermediate risk or high risk patients had been treated with chemotherapy and cranial irradiation according to the ALL BFM-83 protocol. A decrease in amplitudes was observed at the brachial plexus and spinal cord (C7) in the median SEP, and at the knee, spinal cord (Th12), and cortex in the tibial SEP, indicating axonal injury within the entire CNS in the patients with ALL compared with healthy age-, gender-, and height-matched controls. Prolongation of the SEP latencies was found within the spinal cord, indicating demyelination. These SEP changes had persisted for 2 years since the last injection/infusion of vincristine or methotrexate, which are the principal neurotox...Continue Reading

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Citations

Jan 23, 2003·Archives of Disease in Childhood·J RodgersK Windebank
Jun 1, 2010·Pakistan Journal of Biological Sciences : PJBS·A A G TantawyA A N A El Aziz
Apr 7, 2010·Pediatric Hematology and Oncology·Shadi Farzin GoharMelanie Comito
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