Nerve-muscle pedicle implantation facilitates re-innervation of long-term denervated thyroarytenoid muscle in rats

Acta Oto-laryngologica
Satoru MiyamaruE Yumoto

Abstract

Nerve-muscle pedicle (NMP) implantation was effective in the recovery from atrophic changes in long-term denervated thyroarytenoid (TA) muscle. Re-innervation occurred via the transferred nerve. However, the effectiveness of the NMP method may decline with increasing duration of denervation. To evaluate the effects of NMP implantation on long-term denervated rat TA muscle. Wistar rats (n=105) were divided into two groups in which the left recurrent laryngeal nerve (RLN) was transected without (DNV group) or with (NMP group) subsequent NMP implantation, and subgroups of each group were formed depending on the period after RLN transection (immediate to 48 weeks). In the DNV subgroups, we histologically assessed the area of muscle and the number of neuromuscular junctions. In the NMP subgroups, we performed electromyographic, videolaryngoscopic, and histologic assessments. The muscle area and muscle action potentials were evaluated by comparing the treated and untreated sides. The ratio of the number of nerve terminals to that of acetylcholine receptors was also assessed. The TA muscle area was significantly larger in most of the NMP subgroups compared with the DNV subgroups. Muscle action potentials were present in all NMP animal...Continue Reading

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Citations

Jan 25, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ignacio Hernández-MoratoArán Pascual-Font
Sep 18, 2014·The Laryngoscope·Shaum S SridharanMichael C Munin
Nov 23, 2011·Acta Oto-laryngologica·Satoru MiyamaruEiji Yumoto
Jan 22, 2011·The Annals of Otology, Rhinology, and Laryngology·Takashi AoyamaSatoru Miyamaru
Feb 13, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Tetsuji SanukiRyosei Minoda
Apr 27, 2011·The Laryngoscope·Megahed M HassanNarihiro Kodama
Nov 4, 2020·International Journal of Pediatric Otorhinolaryngology·Pierre FayouxSam J Daniel

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