Nerve regeneration and origin of Schwann cells in peripheral nerve allografts in immunologically pretreated rats

Transplantation
K KatsubeS Kawai

Abstract

For peripheral nerve allografts, the conditions for successful nerve regeneration and the possibility of transplanting Schwann cells were examined using a model of pretreated rats. Incomplete immunosuppression was achieved in recipient rats with donor red blood cell infusions given before allogeneic nerve grafting (RBC group). The origin of Schwann cells in the grafts was assessed by immunohistochemical staining from 1 week to 12 weeks after transplantation. In the RBC group, the replacement of donor Schwann cells by recipient cells was detected at 3-8 weeks, with the graft being filled with many of these cells at all times, and successful nerve regeneration was seen after 12 weeks on morphometric and electrophysiologic evaluations. In peripheral nerve allografts, pretreatment with donor-specific blood transfusion did not induce significant immunosuppression compared with allotransplantations of some tissues and organs. Clinically, if the state of immunosuppression can be controlled by RBC transfusion, it is possible that donor tissues may be replaced by recipient tissues and that nerves will regenerate successfully.

References

Nov 1, 1978·Transplantation·L H Toledo-PereyraV R Ramakrishnan
Nov 1, 1980·Experimental Neurology·A A Zalewski, A K Gulati
May 1, 1994·Journal of Neuropathology and Experimental Neurology·R MidhaL E Becker
May 1, 1993·Journal of Reconstructive Microsurgery·O IshidaJ C Firrell

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Citations

Oct 28, 2004·Muscle & Nerve·Ida K FoxSusan E Mackinnon
Nov 1, 2007·Seminars in Plastic Surgery·Ida K Fox, Susan E Mackinnon
Apr 12, 2007·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Marita Pietrucha-DutczakJoanna Lewin-Kowalik

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