Nerve regeneration and reinnervation after limb amputation and replantation: clinical and physiological findings

Muscle & Nerve
C KrarupM A Creager

Abstract

A 22-year-old male was studied 3 1/2-4 1/2 years after a traumatic section-avulsion amputation of the left upper extremity at the level of the distal humerus. The arm was reattached after a cold ischemia time of 4-5 hours and good vascularization was obtained. The ulnar nerve was repaired early with an end-to-end juncture while the median and radial nerves were repaired after seven months delay using a combination of vascularized radial nerve and nonvascularized sural nerve grafts. Some intrinsic hand muscle function had recovered. Pin-prick and touch sensation was present in all digits, although localization of touch stimulation was poor. Evoked motor responses had recovered by 25-50% of control amplitude in ulnar-innervated and by 10-25% in median-innervated muscles. Amplitudes of sensory responses from digit V had recovered by 25% and from digits I and III by 1-5%. Fast-adapting touch receptors had become reinnervated. There was electrophysiological evidence of aberrant sensory regeneration and of abnormal connections between sensory and motor fibers. Digital blood flow measurements suggested the presence of vascular obstruction in vessels of the replanted upper extremity. However, the digital vasoconstriction during cold ex...Continue Reading

References

Apr 1, 1979·Journal of the Neurological Sciences·G Roth
Jan 11, 1975·IEEE Transactions on Bio-medical Engineering·D E HokansonD E Strandness
Apr 1, 1985·Journal of the Neurological Sciences·C Krarup, R W Gilliatt
Aug 1, 1988·Muscle & Nerve·P B ToftH Schmalbruch
Dec 1, 1987·Brain : a Journal of Neurology·H E TorebjörkJ L Ochoa
Sep 1, 1986·The Journal of Hand Surgery·M B Wood, W P Cooney
Oct 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·E Stålberg, J V Trontelj
Apr 1, 1972·Developmental Medicine and Child Neurology·A L Wagner, F Buchthal
May 1, 1981·The Journal of Trauma·M MatsudaM Hosoi
Dec 1, 1980·Acta Physiologica Scandinavica·H E Torebjörk, J L Ochoa
Feb 1, 1965·Journal of Neurology, Neurosurgery, and Psychiatry·P M FULLERTON, R W GILLIATT
May 1, 1962·Archives of Neurology·G SACCOP ROSENFALCK
Dec 1, 1950·The Journal of Comparative Neurology·S SUNDERLAND, K C BRADLEY
Jun 15, 1944·The Journal of Physiology·F K Sanders, J Z Young
Dec 1, 1945·Brain : a Journal of Neurology·S SUNDERLAND

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Citations

Apr 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·S Braune, W Schady
Nov 4, 2000·Journal of Neurosurgery·K WiechN Birbaumer
Oct 10, 2012·Neuroreport·Hikmat HadoushMitsuo Ochi
Apr 27, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Thomas SchoellerGeorg M Huemer
Feb 13, 2001·Experimental Neurology·B GołkaE Małecka-Tendera
Jan 1, 2012·Acta ortopedica brasileira·Renata Gregorio PaulosLuciano Ruiz Torres
Nov 21, 2017·Annals of Neurology·Christian KrarupSimon J Archibald
Oct 18, 2000·Journal of Biomedical Materials Research·V MaquetR Jérôme
May 5, 2021·Neurobiology of Disease·P KomirishettyD W Zochodne

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