Nerve ultrasound for diagnosing chronic inflammatory neuropathy: a multicenter validation study

Neurology
Ingrid J T HerraetsW Ludo van der Pol

Abstract

To validate the diagnostic accuracy of a previously described short sonographic protocol to identify chronic inflammatory neuropathy (CIN), including chronic inflammatory demyelinating polyneuropathy (CIDP), Lewis Sumner syndrome (LSS) and multifocal motor neuropathy (MMN) and to determine the added value of nerve ultrasound to detect treatment-responsive patients compared to nerve conduction studies (NCS) in a prospective multicenter study. We included 100 consecutive patients clinically suspected of CIN in three centers. The study protocol consisted of neurological examination, laboratory tests, NCS and nerve ultrasound. We validated a short sonographic protocol (median nerve at forearm, upper arm, and C5 nerve root) and determined its diagnostic accuracy using the EFNS/PNS criteria of CIDP/MMN (reference standard). In addition, to determine the added value of nerve ultrasound in detecting treatment-responsive patients, we used previously published diagnostic criteria based on clinical, NCS, sonographic findings and treatment response (alternative reference standard). Sensitivity and specificity of the sonographic protocol for CIN according to the reference standard were 87.4% and 67.3%, respectively. Sensitivity and specific...Continue Reading

References

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Jan 22, 2020·Neurology·Ingrid J T HerraetsW Ludo van der Pol

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Citations

Sep 24, 2020·Journal of Neurology·Marieke H J van RosmalenW Ludo van der Pol
Feb 6, 2021·Practical Neurology·Johan A TellemanLeo H Visser
Feb 13, 2021·Diagnostics·Magdalena KramerSophia Willikens
Mar 6, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Karissa L Gable, Lisa D Hobson-Webb
Apr 29, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Johan A TellemanLeo H Visser
Jul 17, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Tabea SeeligerSonja Körner
Jul 31, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Peter Y K Van den BerghHaluk A Topaloglu
Aug 26, 2021·International Journal of General Medicine·Andrew HannafordNeil G Simon

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