NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy

Diabetes Research and Clinical Practice
G PonirakisRayaz A Malik

Abstract

Sensory neuropathy is central to the development of painful neuropathy, and foot ulceration in patients with diabetes. Currently, available QST devices take considerable time to perform and are expensive. NerveCheck is the first inexpensive ($500), portable QST device to perform both vibration and thermal testing and hence evaluate diabetic peripheral neuropathy (DPN). This study was undertaken to establish the reproducibility and diagnostic validity of NerveCheck for detecting neuropathy. 130 subjects (28 with DPN, 46 without DPN and 56 control subjects) underwent QST assessment with NerveCheck; vibration perception and thermal testing. DPN was defined according to the Toronto criteria. NerveCheck's intra correlation coefficient for vibration, cold and warm sensation testing was 0.79 (95% LOA: -4.20 to 6.60), 0.86 (95% LOA: -1.38 to 2.72) and 0.71 (95% LOA: -2.36 to 3.83), respectively. The diagnostic accuracy (AUC) for vibration, cold and warm sensation testing was 86% (SE: 0.038, 95% CI 0.79-0.94), 79% (SE: 0.058, 95% CI 0.68-0.91) and 72% (SE: 0.058, 95% CI 0.60-0.83), respectively. This study shows that NerveCheck has good reproducibility and comparable diagnostic accuracy to established QST equipment for the diagnosis of ...Continue Reading

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Citations

Dec 7, 2016·Diabetes Technology & Therapeutics·Georgios PonirakisRayaz A Malik
Feb 28, 2020·Journal of Clinical Medicine·Raúl Fernández-TorresManuel Gónzalez-Sánchez
Feb 10, 2020·Journal of Neural Transmission·Daniela C RosenbergerRolf-Detlef Treede
Sep 2, 2017·Infectious Diseases of Poverty·Inge WagenaarJan Hendrik Richardus
Dec 22, 2020·Diabetes Research and Clinical Practice·Ariel OdriozolaRayaz A Malik
Mar 3, 2020·Revista española de anestesiología y reanimación·M AvellanalG Díaz-Regañón
Apr 28, 2021·Current Opinion in Supportive and Palliative Care·Maren ReimerRalf Baron
May 20, 2021·Current Opinion in Supportive and Palliative Care·Maren ReimerRalf Baron
Jun 15, 2021·Frontiers in Endocrinology·Josie CarmichaelMitra Tavakoli
Jun 11, 2021·The Journal of Clinical Endocrinology and Metabolism·Cécile ReynèsAgnès Vinet

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