Nervous control of alkaline secretion in the duodenum as studied by the use of cholera toxin in the anaesthetized rat

Acta Physiologica Scandinavica
E A JaupO Lundgren

Abstract

There is experimental evidence for an axon reflex control of alkaline secretion in the rat duodenum. We have investigated if there is also an intramural reflex control of alkaline secretion similar to that demonstrated with regard to the control of the fluid transport in the rat jejunum. Alkaline secretion in the duodenum of an anesthetized rat was continuously monitored using an in situ titration technique. The segment was extrinsically denervated. Exposing the duodenal segment to 80 microg cholera toxin markedly increased alkaline secretion. This response was abolished by hexamethonium (28 micromol (10 mg) kg(-1) body wt), a nicotinic receptor blocker, lidocaine (0.5 mL of a 1% solution on the serosal surface), a local anaesthetic, and nifedipine (5.75 micromol (2 mg) kg(-1) body wt i.v.), a calcium channel blocker. The response to cholera toxin was partially abolished by granisetron (0.11 micromol (40 microg) kg(-1) body wt i.v.), a 5-HT3 receptor blocker. Atropine (1.7 micromol (0.5 mg) kg(-1) body wt i.v.), a muscarinic receptor blocker, had no effect. We therefore conclude that the alkaline secretion in the rat jejunum evoked by cholera toxin exhibits the same pharmacological properties as the fluid secretion caused by th...Continue Reading

References

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Feb 1, 1983·Acta Physiologica Scandinavica·J CassutoO Lundgren
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Jun 1, 1994·Journal of the Autonomic Nervous System·J C BornsteinW A Kunze
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Aug 1, 1997·Acta Physiologica Scandinavica·A Timar PeregrinO Lundgren
Apr 1, 1981·Scandinavian Journal of Gastroenterology·J CassutoO Lundgren

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Citations

Jun 20, 2002·Pharmacology & Toxicology·Ove Lundgren
Jul 2, 2014·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Annalaura RestivoMaria Perla Colombini
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Adrian Allen, Gunnar Flemström
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·O NylanderM Sababi

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