Nervous control of pancreatic endocrine secretion in pigs. II. The effect of pharmacological blocking agents on the response to vagal stimulation

Acta Physiologica Scandinavica
J J HolstJ Fahrenkrug

Abstract

The glucose dependent glucagon and insulin responses to electrical vagal stimulation in anesthetized splanchnicotomized young pigs were studied after administration of various pharmacological blocking agents. Hexamethonium completely abolished the responses, regardless of the glucose level. Atropine was without effect on the glucagon as well as the insulin response, regardless of stimulation frequency, glucose level, or dose of atropine. Neither propranolol nor a combination of propranolol and phenoxybenzamine inhibited the response. Our findings indicate that neither adrenergic fibres nor fibres impinging on muscarinic cholinergic receptors are involved in the pancreatic endocrine response to vagal stimulation.

References

Jan 1, 1979·Acta Physiologica Scandinavica·J J HolstJ Fahrenkrug
Mar 2, 1978·Histochemistry·F SundlerO Schaffalitzky de Muckadell
Mar 1, 1978·The Journal of Clinical Investigation·T W SchwartzF Stadil
Mar 1, 1978·Life Sciences·L I LarssonO B Schaffalitzky de Muckadell
Oct 1, 1974·Endocrinology·A KanetoK Kosaka
Aug 1, 1973·The American Journal of Physiology·R N Bergman, R E Miller
Sep 1, 1967·The Journal of Physiology·P M Daniel, J R Henderson
Jul 1, 1967·Diabetes·L A FrohmanR Javid

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Citations

Jan 1, 1989·Acta diabetologica latina·D G Lambert, T W Atkins
Feb 1, 1983·Journal of the Autonomic Nervous System·H R BerthoudB Jeanrenaud
Sep 1, 1986·Journal of the Autonomic Nervous System·J J HolstO V Nielsen
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S OdaY Sasaki
Jan 1, 2013·Diabetes·Claire B BonalPedro L Herrera
Jul 3, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Astrid PlamboeckJens J Holst
Oct 24, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Simon VeedfaldJens Juul Holst
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Q MeiG J Taborsky
Dec 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·F C BrunicardiD K Andersen

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