Nervous system pathology: the fibrin perspective

Biological Chemistry
Katerina Akassoglou, S Strickland

Abstract

Studies of extracellular matrix (ECM) biology in the nervous system have mainly focused on laminin, fibronectin and tenascin-R, proteins that are present during nervous system development and normal function. However, during disease, fibrin, which physiologically is not present in the nervous tissue, is detected at nervous tissue lesions. This review summarizes evidence that correlates fibrin deposition with neuropathology and presents recent findings on cellular mechanisms and intracellular signaling pathways regulated by fibrin that might contribute to nervous system disease.

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Citations

Nov 1, 2011·Seminars in Immunopathology·Dimitrios Davalos, Katerina Akassoglou
Dec 4, 2003·Experimental Cell Research·Michael A Chernousov, David J Carey
Mar 8, 2007·Annual Review of Neuroscience·Zu-Lin ChenSidney Strickland
Apr 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christian SchachtrupKaterina Akassoglou
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katerina AkassoglouSidney Strickland
Jul 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christian SchachtrupKaterina Akassoglou
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Apr 22, 2014·The Veterinary Journal·Cristian de la FuenteSònia Añor
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