Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis

Peptides
Chanel RobinsonPatrick H Dessein

Abstract

Nesfatin is an anti-inflammatory molecule that reduces atherosclerotic cardiovascular risk. By contrast, visfatin has pro-inflammatory properties and is pro-atherogenic. We examined the potential impact of nesfatin and visfatin on atherosclerotic disease in 232 (113 black and 119 white) consecutive rheumatoid arthritis (RA) patients from 2 centers. Independent relationships of nesfatin and visfatin concentrations with metabolic risk factors, endothelial activation, carotid atherosclerosis and altered plaque stability were determined in multivariable regression models. Rheumatoid factor (RF) positivity was associated with both nesfatin (β = 0.650, p < 0.0001) and visfatin levels (β = 0.157, p = 0.03). Visfatin concentrations were related to increased diastolic blood pressure (β = 4.536, p = 0.01) and diabetes prevalence (β = 0.092, p = 0.04). Nesfatin levels were associated with reduced carotid intima-media thickness (β = -0.017, p = 0.008). Nesfatin (β = 0.116, p = 0.001) and visfatin concentrations (β = 0.234, p = 0.001) were related to those of matrix metalloproteinase-2 (MMP-2), a plaque stability mediator. Nesfatin and visfatin concentrations were directly correlated (Spearman's rho = 0.516). The nesfatin-MMP-2 and visfatin...Continue Reading

Citations

Mar 29, 2019·International Journal of Molecular Sciences·Iona J MᵃᶜDonaldChih-Hsin Tang
Sep 28, 2018·Clinical Reviews in Allergy & Immunology·Federico CarboneMaurizio Cutolo
Dec 26, 2018·Journal of Immunology Research·Piero RuscittiRoberto Giacomelli
Aug 2, 2019·Diabetology & Metabolic Syndrome·Long-Yi ZhengQin Huang
Aug 25, 2019·International Journal of Molecular Sciences·Mar CarriónElena Neumann
Oct 12, 2018·Journal of the Endocrine Society·Martha A Schalla, Andreas Stengel
Jan 28, 2021·Cells·Elena NeumannUlf Müller-Ladner

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