Nesfatin-1 influences the excitability of glucosensing neurons in the hypothalamic nuclei and inhibits the food intake

Regulatory Peptides
Xi ChenZheng-Yao Jiang

Abstract

Nesfatin-1 is a recently discovered neuropeptide that has been shown to decrease food intake after lateral, third, or fourth brain ventricle, cisterna magna administration, or PVN injection in ad libitum fed rats. With regards to the understanding of nesfatin-1 brain sites of action, additional microinjection studies will be necessary to define specific nuclei, in addition to the PVN, responsive to nesfatin-1 to get insight into the differential effects on food intake. In the present study, we evaluated nesfatin-1 action to modulate food intake response upon injection into the specific hypothalamic nuclei (PVN, LHA and VMN) in freely fed rats during the dark phase. We extend previous observations by showing that the nesfatin-1 (50 pmol) injected before the onset of the dark period significantly reduced the 1 to 5 h cumulative food intake in rats cannulated into the PVN, LHA, but not in rats cannulated into the VMN. Glucosensing neurons located in the hypothalamus are involved in glucoprivic feeding and homeostatic control of blood glucose. In order to shed light on the mechanisms by which nesfatin-1 exerts its satiety-promoting actions, we examined the effect of nesfatin-1 on the excitability of hypothalamic glucosensing neuron...Continue Reading

References

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Citations

Nov 14, 2013·Journal of Molecular Neuroscience : MN·Chen LiHong Jiang
Mar 26, 2013·Endocrine·Suleyman Aydin
Jun 28, 2015·Peptides·Andreas Stengel
Aug 29, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A StengelY Taché
May 30, 2013·Behavioural Brain Research·Jason M Moreau, John Ciriello
Oct 19, 2016·The Journal of Endocrinology·Riccardo DoreCarla Schulz
Dec 1, 2012·Balsaeng'gwa saengsig·Jinhee Kim, Hyunwon Yang
Sep 26, 2013·Endocrinology·Sandra Feijóo-BandínFrancisca Lago
May 10, 2017·Balsaeng'gwa saengsig·Sojeong SeonHyunwon Yang
Nov 2, 2019·The Chinese Journal of Physiology·Oktay KayaLevent Ozturk
Sep 14, 2018·Frontiers in Endocrinology·Ayelén M BlancoSuraj Unniappan
Mar 24, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tommaso AngeloneTeresa Pasqua
Aug 1, 2021·General and Comparative Endocrinology·Krittika DotaniaUmesh Rai

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