PMID: 28511756Apr 1, 2015Paper

Nested Melanoma, a New Morphological Variant of Superficial Spreading Melanoma with Characteristic Dermoscopic Features

Acta dermatovenerologica Croatica : ADC
Mikela Petković, Ružica Jurakić Tončić

Abstract

A new morphological variant of superficial spreading melanoma (SSM) was first described by Kutzner et al. (1) and named "melanoma composed exclusively or predominantly of large nests"; it was later named "nested melanoma" (NM) (2,3). Clinically, lesions are larger in diameter (>6 mm), mostly showing typical clinical features of melanoma (the ABCD rule), and significantly different from all other pigmented lesions (the "ugly duckling sign") (1). The majority of NM is found on the trunk and limbs of patients older than 60 years (1-9). Dermoscopy shows typical features of melanoma (asymmetry, irregular blotches, atypical pigmented network, multicomponent structure, irregular dots, and globules) followed by the "typical" dermoscopic finding of a globular pattern with globules varying in shape, color, and distribution (1,3). It is known that flat nevi in the elderly present with a reticular or structureless dermoscopic global pattern, along with the fact that total nevi count decreases with advancing age due to involution of nevi (4,5). Therefore, a globular pattern is uncommon in the elderly, and this finding should always invoke a high suspicion of melanoma. Histological diagnosis may be difficult because of the predominantly nest...Continue Reading

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Annales de dermatologie et de vénéréologie
M-H JegouI Penchet
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Heinz KutznerThomas Wiesner
Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
W Stolz, M Landthaler
© 2022 Meta ULC. All rights reserved