Apr 10, 2020

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein harbors a conserved BH3-like motif

BioRxiv : the Preprint Server for Biology
V. NavratilAbdel Aouacheria

Abstract

Following the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) in 2002 and Middle East Respiratory Syndrome coronavirus (MERS-CoV) in 2012, the novel coronavirus SARS-CoV-2 emerged at the end of 2019 as a highly pathogenic infectious agent that rapidly spread around the world. SARS-CoV-2 shares high sequence homology with SARS-CoV and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical symptoms similar to those reported for SARS-CoV. Like other betacoronaviruses, SARS-CoV-2 encode four major structural proteins: Spike (S), Membrane (M), Nucleocapsid (N) and Envelope (E). SARS-CoV E protein is abundant in infected cells and plays a crucial role in viral particle assembly. Moreover, SARS coronaviruses lacking E are attenuated in vivo, suggesting that CoV E may act as a critical virulence factor not only in SARS-CoV but also in the case of the new coronavirus SARS-CoV-2. Ectopic expression of SARS-CoV E was previously shown to trigger apoptosis (cell suicide) of T lymphocytes, lymphopenia being a common feature observed in fatal cases following viral infections. Importantly, T-cell apoptosis was shown to involve interaction between the C-terminal region of SARS-CoV E and the Bcl-2 family...Continue Reading

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Mentioned in this Paper

Study
Enterobacteriaceae
Conjugation
Genes
Carbapenems
Transposition of Intestine (Disorder)
Public Health Surveillance
Recombination, Genetic
DNA Sequence - Cloning Site
Cellular Transposition

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Carbapenems (ASM)

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