Nestin expression identifies ependymoma patients with poor outcome.

Brain Pathology
Till MildeA Korshunov

Abstract

Ependymomas are primary brain tumors found throughout the central nervous system (CNS) in children and adults. Currently, many treatment protocols stratify grade I and II ependymomas as low-risk tumors, whereas grade III anaplastic ependymomas are considered high-risk tumors. The prognostic significance of World Health Organization (WHO) grade II or III, however, remains debated, and it is furthermore increasingly recognized that the pathologic differentiation between grades II and III is arbitrary in daily practice, thus resulting in imprecise risk stratification. Therefore, prognostic markers enabling more precise stratification to guide treatment decisions are urgently needed. An analysis of n = 379 tumor samples revealed that protein expression of nestin, a marker for neural stem and progenitor cells established as a routine staining in most neuropathology centers, is associated with poor outcome in intracranial ependymomas. Most importantly, nestin-positive grade II ependymomas have the same prognosis as grade III ependymomas. Multivariable analysis demonstrates that nestin positivity is an independent marker for poor progression-free survival (PFS) and overall survival (OS). Gene expression analysis for transcriptionally ...Continue Reading

References

Jun 19, 1992·International Journal of Cancer. Journal International Du Cancer·M FerrariniC Rugarli
Sep 1, 1994·Developmental Biology·A M KachinskyJ B Miller
May 1, 1996·Journal of Neuropathology and Experimental Neurology·R E McLendonH S Friedman
Aug 1, 1996·Controlled Clinical Trials·M Schemper, T L Smith
Sep 4, 1999·Statistics in Medicine·E GrafM Schumacher
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Per M AlmqvistGlenda Hendson
Mar 1, 2002·Experimental Neurology·Neil Duggal, Robert R Hammond
Apr 16, 2002·British Journal of Cancer·M CarterD W Ellison
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Oct 18, 2005·Cancer Cell·Michael D TaylorRichard J Gilbertson
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yasuyuki AmohRobert M Hoffman
Feb 8, 2006·Nature Cell Biology·Keisuke KajiBrian Hendrich
Mar 15, 2006·Neuroscience Letters·Davide SchifferIlaria Tamagno
Apr 6, 2006·Bioinformatics·Ryota Suzuki, Hidetoshi Shimodaira
Jul 6, 2007·Journal of Neuro-oncology·Yue-Hui MaJanka Held-Feindt
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Sep 18, 2007·Journal of Clinical Pathology·X H YangA P Xiang
Dec 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tarik TihanElisabeth J Rushing
Mar 11, 2008·Cancer Genetics and Cytogenetics·Camelia-Maria MonoranuWolfgang Roggendorf
Oct 1, 2008·Cancer Letters·Olaf WittIna Oehme
Dec 26, 2008·Journal of Experimental & Clinical Cancer Research : CR·Mingyu ZhangJiasheng Fang
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stéphanie PugetGilles Vassal
Apr 22, 2009·Biostatistics·Mark A van de WielWessel N van Wieringen
Feb 17, 2010·European Journal of Dermatology : EJD·Kenichi TanabeKensei Katsuoka
Mar 30, 2010·The British Journal of Dermatology·A FusiU Keilholz
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrey KorshunovStefan Pfister
Dec 21, 2010·Cancer Research·Igor ShatsJoseph R Nevins
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiaowei YanQiang Tian
Jun 2, 2011·Journal of Negative Results in Biomedicine·David W EllisonRichard G Grundy

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Citations

Sep 14, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rita G LadsteinLars A Akslen
Feb 19, 2013·Future Oncology·Felipe AndreiuoloJacques Grill
Apr 4, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·X DuA P Xiang
Apr 9, 2015·Acta Neuropathologica Communications·Jonas EckerTill Milde
Sep 10, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yuan Y ThompsonMichael D Taylor
Apr 18, 2015·Brain : a Journal of Neurology·Daniel Garcia-OvejeroEduardo Molina-Holgado
Apr 29, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C ShuJ Wang
Jul 18, 2019·Scientific Reports·Durgagauri H SabnisBeth Coyle
Aug 29, 2014·Cellular Oncology (Dordrecht)·Ekaterini Christina TampakiGregory Kouraklis
Nov 17, 2016·Chinese Journal of Cancer·Vijay Ramaswamy, Michael D Taylor
Oct 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hazel A RogersRichard G Grundy
Aug 24, 2021·Clinical Medicine Insights. Oncology·Anna Szymańska-ChabowskaMariusz Chabowski

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