Nestin expression in high-grade osteosarcomas and its clinical significance

Oncology Reports
Iva ZamboRenata Veselska

Abstract

Nestin has been detected in various malignancies and its expression correlates with advanced grade in some neoplasms. The aim of this study was to examine nestin expression in high-grade osteosarcomas and to determine its prognostic value. Using immunohistochemistry and immunofluorescence, we evaluated nestin expression in tumor tissue samples from 45 patients with high-grade osteosarcomas. In both methods, the frequency of nestin-positive tumor cells was classified into three categories (1+, 2+ and 3+ for immunohistochemistry; 1F+, 2F+ and 3F+ for immunofluorescence) and clinicopathological correlations were statistically evaluated and analyzed. Nestin-positive tumor cells were detected in all of the examined osteosarcomas using both immunohistochemistry and immunofluorescence, although the proportion of undoubtedly positive neoplastic cells varied in individual samples from a few nestin-positive tumor cells to diffuse nestin positivity. High levels of nestin expression detected by immunofluorescence (2F+ and 3F+) were associated with worse clinical outcomes (OS, p=0.031; EFS, p<0.001). However, high levels of nestin expression as measured by immunohistochemistry trended towards shorter patient survival rates but did not reach...Continue Reading

Citations

May 6, 2015·Cancer Science·Jakub Neradil, Renata Veselska
Jun 18, 2016·Cancer Biomarkers : Section a of Disease Markers·Iva ZamboRenata Veselska
Apr 26, 2017·Frontiers in Pharmacology·Francesco R EvolaGiuseppe Sessa

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