Nestin expression in neuroepithelial tumors

Neuroscience Letters
Davide SchifferIlaria Tamagno

Abstract

Nestin is a marker of early stages of neurocytogenesis. It has been studied in 50 neuroepithelial tumors, mostly gliomas of different malignancy grades, by immunohistochemistry, immunofluorescence, immunoblotting, and confocal microscopy and compared with GFAP and Vimentin. As an early marker of differentiation, Nestin is almost not expressed in diffuse astrocytomas, variably expressed in anaplastic astrocytomas and strongly and irregularly expressed in glioblastomas. Negative in oligodendrogliomas, it stains ependymomas and shows a gradient of expression in pilocytic astrocytomas. In glioblastomas, Nestin distribution does not completely correspond to that of GFAP and Vimentin with which its expression varies in tumor cells in a complementary way, as confirmed by confocal microscopy. Tumor cells can thus either derive from or differentiate toward the neurocytogenetic stages. Hypothetically, they could be put in relation with radial glia where during embriogenesis the three antigens are successively expressed. Completely negative cells of invasive or recurrent glioblastomas may represent malignant selected clones after accumulation of mutations or early stem cells not expressing antigens.

References

Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·N UchidaI L Weissman
Nov 28, 2001·Current Opinion in Neurology·E C Holland
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Per M AlmqvistGlenda Hendson
Mar 1, 2002·Experimental Neurology·Neil Duggal, Robert R Hammond
Oct 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shin-ichi SakakibaraHideyuki Okano
May 23, 2003·Glia·Dennis A Steindler, Eric D Laywell
Dec 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Houman D HemmatiHarley I Kornblum
Feb 24, 2004·Journal of Hematotherapy & Stem Cell Research·Daniele BottaiL Angelo Vescovi
Aug 19, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Guido Reifenberger, Vincent Peter Collins
Sep 21, 2004·Oncogene·Sheila K SinghPeter B Dirks
Sep 21, 2004·Oncogene·Muhammad Al-Hajj, Michael F Clarke
Oct 2, 2004·Neurosurgery·Koichi UchidaTakeshi Kawase
Feb 22, 2005·Current Opinion in Neurobiology·Leah Ever, Nicholas Gaiano
Jun 1, 2005·Experimental Cell Research·Elena I Fomchenko, Eric C Holland

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Citations

Dec 20, 2007·Neurosurgical Review·K SakuradaT Kayama
Jan 29, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kyung-Jung KimMin-Cheol Lee
Aug 27, 2011·Journal of Oncology·Valentina CalderaDavide Schiffer
Jan 29, 2011·World Journal of Gastroenterology : WJG·Toshiyuki IshiwataZenya Naito
Jun 24, 2008·Cancer Investigation·A Shervington, C Lu
Nov 11, 2011·Journal of Medical Primatology·Wijit BanlunaraHiroyuki Nakayama
May 10, 2012·Brain Pathology·Till MildeAndrey Korshunov
Jul 19, 2013·Journal of Neurochemistry·Federico S RodríguezFrancisco J Nualart
May 17, 2014·BioMed Research International·Davide SchifferAntonio Melcarne
Oct 19, 2012·Toxicologic Pathology·Mariko NagataniKazuyuki Uchida
Apr 27, 2010·Veterinary Pathology·T IdeH Nakayama
Sep 18, 2007·Journal of Clinical Pathology·X H YangA P Xiang
Jul 11, 2006·Journal of Neuro-oncology·Ilaria Tamagno, Davide Schiffer
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annunziato MangiolaGigliola Sica
Jul 24, 2021·Journal of Neuropathology and Experimental Neurology·Michael ProsniakD Craig Hooper
Dec 26, 2008·Journal of Experimental & Clinical Cancer Research : CR·Mingyu ZhangJiasheng Fang
Jun 24, 2021·Molecular Cancer Research : MCR·Qinglin WangZeng-Jie Yang

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