Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease

Journal of the Neurological Sciences
Yuji MizunoKoichi Okamoto

Abstract

Nestin, an intermediate filament protein, is mainly expressed in neural progenitor/stem cells in the central nervous system. Recently, we reported that nestin is expressed in Purkinje cells in patients with Creutzfeldt-Jakob disease (CJD). In this study, we examined a total of 19 CJD cerebella to analyze the intensity and pattern of nestin immunoreactivity of Purkinje cells in different pathological stages of degeneration in the cerebellar cortex. The results showed that the Purkinje cells were immunoreactive with nestin regardless of the severity of degenerative cerebellar cortex. Furthermore, we noted several different types of nestin immunoreactivity, indicated by diffuse and fine, coarse, and inclusion-like immunostainings within Purkinje cell bodies as well as dot-like staining outside of the cell bodies. In contrast, on examination of cerebella from non-CJD patients, 6 of 30 cases showed nestin immunoreactivity to a lesser extent. Thus, nestin-positive Purkinje cells are more common in CJD cerebella than in non-CJD cerebella. Although the mechanism of nestin expression in Purkinje cells is not yet understood, we suggest that such nestin-positive Purkinje cells are being reactivated to survive the cell death.

References

Jan 1, 1994·Acta Neuropathologica·J HiratoH Yamanouchi
Aug 14, 1999·The Journal of Biological Chemistry·C EliassonM Pekny
Aug 10, 2000·Neuropathology : Official Journal of the Japanese Society of Neuropathology·S TanakaE Ohama
Feb 17, 2001·Molecular and Cellular Neurosciences·A KawaguchiH Okano
May 5, 2004·The Journal of Clinical Investigation·Lixin SunHoward A Fine
Jul 28, 2004·Neuroscience Letters·Yuji MizunoKoichi Okamoto

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Citations

Apr 15, 2011·PloS One·Michael L HendricksonRonald E Kalil
Jul 22, 2010·Journal of Neuroscience Research·Marco PuglieseNicole Mahy
Aug 16, 2016·Cell and Tissue Research·David GrundmannKarl-Herbert Schäfer
Dec 19, 2013·Experimental and Therapeutic Medicine·Chenyun XiaGuoyuan Zhang

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