Nestin in the temporal neocortex of the intractable epilepsy patients.

Neurochemical Research
Liang WangZheng Xiao

Abstract

Nestin is one kind of intermediate filament protein, which is considered as a typical marker of neural precursor cells. Considerable evidence supports nestin may have actively functions in neurogenesis and gliosis. Our aim was to investigate nestin expression in the temporal neocortex of patients with intractable epilepsy (IE), and then to discuss the possible role of nestin in IE. Tissue samples from the temporal neocortex of 32 patients who had surgery for IE were used to detect nestin expression by immunohistochemistry, immunofluorescence. We compared these tissues with 12 histologically normal temporal neocortex from intracranial hypertension patients who had decompression procedures. In this study, we found some nestin positive cells in the normal temporal neocortex, but in the intractable epilepsy, they were upregulated, increasing with length of course and seizure frequency. Optical density (OD) value in epileptic tissue was determined 0.246 +/- 0.030, and 0.134 +/- 0.040 in the control (P < 0.05). Double lables of immunofluorescence showed some nestin positive cells coexpression with glial fibrillary acidic protein (GFAP), while some coexpression with microtubule-associated protein-2 (MAP(2)). These findings provided so...Continue Reading

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Citations

Feb 1, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaya NagaishiYoichi Nakazato
Mar 25, 2011·Medical Hypotheses·Min FangXue-Feng Wang
Jul 9, 2010·Neuropathology and Applied Neurobiology·M ParadisiL Calzà
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Jul 14, 2010·Journal of the Neurological Sciences·Liang WangXuefeng Wang
Dec 12, 2020·The European Journal of Neuroscience·Iman Imtiyaz Ahmed Juvale, Ahmad Tarmizi Che Has
Jun 17, 2021·Chemical Biology & Drug Design·Nadia PerveenImran Imran

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