Nestin upregulation characterizes vascular remodeling secondary to hypertension in the rat

American Journal of Physiology. Heart and Circulatory Physiology
Kim TardifAngelino Calderone

Abstract

Proliferation and hypertrophy of vascular smooth muscle cells represent hallmark features of vessel remodeling secondary to hypertension. The intermediate filament protein nestin was recently identified in vascular smooth muscle cells and in other cell types directly participated in proliferation. The present study tested the hypothesis that vessel remodeling secondary to hypertension was characterized by nestin upregulation in vascular smooth muscle cells. Two weeks after suprarenal abdominal aorta constriction of adult male Sprague-Dawley rats, elevated mean arterial pressure increased the media area and thickness of the carotid artery and aorta and concomitantly upregulated nestin protein levels. In the normal adult rat carotid artery, nestin immunoreactivity was observed in a subpopulation of vascular smooth muscle cells, and the density significantly increased following suprarenal abdominal aorta constriction. Filamentous nestin was detected in cultured rat carotid artery- and aorta-derived vascular smooth muscle cells and an analogous paradigm observed in human aorta-derived vascular smooth muscle cells. ANG II and EGF treatment of vascular smooth muscle cells stimulated DNA and protein synthesis and increased nestin prot...Continue Reading

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Citations

Nov 18, 2015·Journal of Cellular Physiology·Andréanne ChabotAngelino Calderone
Aug 24, 2017·Journal of Cellular Physiology·Vanessa HertigAngelino Calderone
Mar 2, 2018·Frontiers in Cell and Developmental Biology·Angelino Calderone

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