Abstract
Net sulfatide synthesis, galactosylceramide sulfotransferase (EC 2.8.2.11) and arylsulfatase A (EC 3.1.6.1) activities were measured in two brain regions, cerebrum and cerebellum, of normal and jimpy mice during postnatal development. In normally myelinating mice, two phases of increasing rates of net sulfatide synthesis were observed, the first coinciding with oligodendrocyte proliferation and the second with myelination. Net sulfatide synthesis was quantitatively higher in the cerebellum than in the cerebrum. In both brain regions, the developmental patterns of net sulfatide synthesis were related to the activity patterns of both galactosylceramide sulfotransferase and arylsulfatase A. In jimpy mice, a neurological mutant showing hypomyelination in brain, the first phase of net sulfatide synthesis was preserved in both brain regions and galactosylceramide sulfotransferase and arylsulfatase A activities were normal up to 12 days. However, during the phase in which myelination occurred in controls, the net sulfatide synthesis in both brain regions of jimpy mice was zero or even negative. The sulfatide deficit was larger in the cerebellum than in the cerebrum. In both mutant brain parts, galactosylceramide sulfotransferase activ...Continue Reading
References
Aug 11, 1977·Biochimica Et Biophysica Acta·T BurkartU N Wiesmann
Jan 1, 1977·Neuroscience·T BurkartN N Herschkowitz
Jan 23, 1975·Biochimica Et Biophysica Acta·K Stinshoff, H Jatzkewitz
Feb 15, 1977·Life Sciences·A A FarooquiP Mandel
Mar 29, 1979·Biochimica Et Biophysica Acta·G Nonaka, Y Kishimoto
Jul 14, 1977·Nature·C Meier, A Bischoff
Oct 1, 1976·The Journal of Comparative Neurology·R P SkoffA Stocks
Dec 9, 1976·Nature·R P Skoff
Jul 8, 1975·Biochemical and Biophysical Research Communications·T J FlynnR A Pieringer
Jun 1, 1970·Archives of Biochemistry and Biophysics·M T PorterH Kihara
May 1, 1973·Journal of Neurochemistry·N M NeskovicP Mandel
May 1, 1973·The Biochemical Journal·M WorwoodF A Rose
Jan 31, 1974·Experimental Brain Research·L L SarlieveP Mandel
Jan 1, 1968·Physiological Reviews·R P Bunge
Jul 20, 1972·Brain Research·J M MatthieuN Herschkowitz
Jan 31, 1972·Biochemical and Biophysical Research Communications·A T CampagnoniJ Sampugna
Jul 1, 1971·Journal of Neurochemistry·N HerschkowitzA Bischoff
Mar 25, 1968·Biochimica Et Biophysica Acta·E Mehl, H Jatzkewitz
Mar 1, 1968·Journal of Neurochemistry·N HerschkowitzE M Shooter
Oct 1, 1968·Journal of Neurochemistry·N HerschkowitzE M Shooter
Mar 1, 1969·Journal of Neurochemistry·D M Bowen, N S Radin
Jul 1, 1969·Journal of Neurochemistry·N HerschkowitzR Herndon
Jul 1, 1967·Journal of Neurochemistry·G M McKhann, W Ho
Dec 1, 1971·FEBS Letters·L L. SarlieveP Mandel
Apr 17, 1964·Science·R L SIDMANS H APPEL
May 3, 1965·Biochemical and Biophysical Research Communications·E MEHL, H JATZKEWITZ
Citations
Apr 15, 1981·Developmental Biology·T BurkartU N Wiesmann
Feb 1, 1984·Journal of Neurochemistry·J A BenjaminsK Beyer
Mar 1, 1984·Journal of Neurochemistry·A T CampagnoniN Baumann
Oct 1, 1982·Journal of Neurochemistry·E AokiS Kashiwamata
Jan 1, 1986·Journal of Neurochemistry·T KunishitaY Katsuie
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J Rosenfeld, V L Friedrich
Mar 12, 1990·Biochimica Et Biophysica Acta·R H van der PalM Lopes-Cardozo
Jan 1, 1985·Progress in Lipid Research·P S Sastry