NETosis in Neonates: Evidence of a Reactive Oxygen Species-Independent Pathway in Response to Fungal Challenge

The Journal of Infectious Diseases
Angel S ByrdJonathan S Reichner

Abstract

Release of neutrophil extracellular traps (NETs) is a significant antimicrobial host defense mechanism in adults. In neonates, fungal sepsis is a frequent cause of morbidity and mortality and may be a consequence of inadequate neutrophil defense functions. Like neutrophils from adult donors, we found that neutrophils from neonates formed robust cellular aggregates and released NETs in response to fungal β-glucan and Candida albicans hyphae when presented with extracellular matrix. Therefore, in response to fungal stimulation, neonatal neutrophils are capable of NETosis. Neonate susceptibility to fungal infections may not be due to an inability of their neutrophils to produce NETs.

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Citations

Sep 7, 2016·The Journal of Clinical Investigation·Christian C YostGuy A Zimmerman
Oct 5, 2016·Frontiers in Immunology·Xian M O'Brien, Jonathan S Reichner
Nov 11, 2016·Scientific Reports·Duc Ninh NguyenPer T Sangild
Aug 23, 2019·Scientific Reports·A S ByrdG A Okoye
Mar 16, 2017·Frontiers in Pediatrics·Shelley Melissa LawrenceVictor Nizet
Apr 1, 2017·Frontiers in Immunology·Christina MichalskiPascal M Lavoie
Apr 19, 2017·British Journal of Haematology·David C Dale
Oct 7, 2017·Frontiers in Cellular and Infection Microbiology·Marcin ZawrotniakMaria Rapala-Kozik
May 10, 2017·PloS One·Tamara HoppenbrouwersMoniek P M de Maat
May 8, 2018·Cell Death Discovery·Dhia AzzouzNades Palaniyar
Jun 20, 2019·Nature Reviews. Nephrology·Christoph DanielMartin Herrmann
Dec 19, 2017·Cell and Tissue Research·Weronika Ortmann, Elzbieta Kolaczkowska
Jul 15, 2020·Annual Review of Cell and Developmental Biology·Hawa Racine ThiamClare M Waterman
Apr 4, 2021·Journal of Fungi·Thomas J WilliamsDarius Armstrong-James

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