Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland.

Journal of Cellular Physiology
Luigi StrizziDavid S Salomon

Abstract

Netrin-1 has been shown to regulate the function of the EGF-like protein Cripto-1 (Cr-1) and affect mammary gland development. Since Cr-1 is a target gene of Nanog and Oct4, we investigated the relationship between Netrin-1 and Cr-1, Nanog and Oct4 during different stages of development in the mouse mammary gland. Results from histological analysis show that exogenous Netrin-1 was able to induce formation of alveolar-like structures within the mammary gland terminal end buds of virgin transgenic Cripto-1 mice and enhance mammary gland alveologenesis in early pregnant FVB/N mice. Results from immunostaining and Western blot analysis show that Netrin-1, Nanog and Oct4 are expressed in the mouse embryonic mammary anlage epithelium while Cripto-1 is predominantly expressed outside this structure in the surrounding mesenchyme. We find that in lactating mammary glands of postnatal FVB/N mice, Netrin-1 expression is highest while Cripto-1 and Nanog levels are lowest indicating that Netrin-1 may perform a role in the mammary gland during lactation. HC-11 mouse mammary epithelial cells stimulated with lactogenic hormones and exogenous soluble Netrin-1 showed increased beta-casein expression as compared to control thus supporting the pot...Continue Reading

References

Dec 1, 1993·Differentiation; Research in Biological Diversity·A SapinoG Bussolati
Dec 1, 1995·Current Opinion in Cell Biology·G M Keller
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·B P ZambrowiczP Soriano
Apr 14, 1999·Cell Death and Differentiation·C C NiemeyerE D Adamson
May 20, 2000·Journal of Mammary Gland Biology and Neoplasia·M C NevilleR C Hovey
May 20, 2000·Journal of Mammary Gland Biology and Neoplasia·T L WoodwardS Z Haslam
Jan 1, 1996·Journal of Mammary Gland Biology and Neoplasia·D Medina
May 23, 2001·Breast Cancer Research and Treatment·C BiancoD S Salomon
Jan 17, 2003·Cell Research·Guang Jin PanDuanqing Pei
Oct 29, 2003·The Journal of Cell Biology·Silvia ParisiGabriella Minchiotti
Aug 27, 2005·Oncogene·Luigi StrizziDavid Salomon
Oct 19, 2005·Nature Reviews. Molecular Cell Biology·Lothar Hennighausen, Gertraud W Robinson
Mar 22, 2006·Pediatric Research·Hao Wu, Yi Eve Sun
May 26, 2006·The American Journal of Pathology·Hong YuXiaowei Xu
Jul 1, 2006·Science·Brent D WilsonDean Y Li
Jul 18, 2006·Current Opinion in Genetics & Development·Toru Kondo
Aug 29, 2006·PLoS Genetics·Beatrice Howard, Alan Ashworth
Oct 31, 2006·The Journal of Pathology·L StrizziD S Salomon
Jan 11, 2007·Cell Research·Guangjin Pan, James A Thomson
Jan 27, 2007·Current Opinion in Neurobiology·Jennifer Round, Elke Stein
Jul 17, 2007·Biochemical and Biophysical Research Communications·Helene MörwaldChristian Wechselberger
Sep 14, 2007·Nature Reviews. Cancer·John Stingl, Carlos Caldas
Nov 17, 2007·Advanced Drug Delivery Reviews·Nathaniel S HwangJennifer Elisseeff

❮ Previous
Next ❯

Citations

Aug 13, 2010·Cold Spring Harbor Perspectives in Biology·John Muschler, Charles H Streuli
Dec 17, 2009·The American Journal of Pathology·Kelly E FathersMorag Park
May 1, 2012·The American Journal of Pathology·Maria C RangelCaterina Bianco
Sep 13, 2018·Current Medicinal Chemistry·Annamaria Sandomenico, Menotti Ruvo
Dec 18, 2015·Oncotarget·Patricia Fernández-NogueiraPedro Gascón
Feb 13, 2009·American Journal of Physiology. Renal Physiology·Weiwei WangGanesan Ramesh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.