Netrin-1 plays a role in the effect of moderate exercise on myocardial fibrosis in rats

PloS One
Zhou DaliangLi Weimin

Abstract

This study aimed to investigate the effect of aerobic exercise on the expression of neitrin-1,DCC receptor and myocardial fibrosis in rats with acute myocardial infarction. Twenty-four rats were randomly divided into three groups: the sham group (n = 8), the acute myocardial infarction (AMI) model group (n = 8), and the aerobic exercise treatment after acute myocardial infarction group (ET) (n = 8). After 10 weeks, the serum levels of netrin-1, tumor necrosis factor alpha α (TNF-α), and interleukin 6 (IL-6) were measured. The expression of matrix metalloproteinase 2 and 9 (MMP2, 9), and their inhibitor, tissue inhibitor of metalloproteinase 2 (TIMP2), myocardial netrin-1, and the deleted in colorectal cancer (DCC) receptor were evaluated. Histopathological results were also evaluated. The collagen volume fraction of the myocardial tissues was also calculated. Compared with the sham group, in the AMI and ET groups, left ventricular end diastolic pressure (LVEDP) were increased, while left ventricular systolic pressure (LVSP), and left ventricular pressure maximal rate of rise and fall (± dp/dtmax) were significantly decreased (P<0.05,). Compared with the AMI group, in the ET group, LVSP, and ±dp/dtmax were significantly increase...Continue Reading

References

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Citations

Aug 9, 2020·Oxidative Medicine and Cellular Longevity·Diego Fernando BatistaLeonardo Antônio Mamede Zornorff
Nov 18, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Fen ZhuDongsheng Li
Jan 30, 2021·Basic Research in Cardiology·Marius KellerPeter Rosenberger

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
electrophoresis

Software Mentioned

Motic Med
SPSS
Bio
Rad Image Lab

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