Netrin-1/DCC-mediated PLCγ1 activation is required for axon guidance and brain structure development

EMBO Reports
Du-Seock KangPann-Ghill Suh

Abstract

Coordinated expression of guidance molecules and their signal transduction are critical for correct brain wiring. Previous studies have shown that phospholipase C gamma1 (PLCγ1), a signal transducer of receptor tyrosine kinases, plays a specific role in the regulation of neuronal cell morphology and motility in vitro However, several questions remain regarding the extracellular stimulus that triggers PLCγ1 signaling and the exact role PLCγ1 plays in nervous system development. Here, we demonstrate that PLCγ1 mediates axonal guidance through a netrin-1/deleted in colorectal cancer (DCC) complex. Netrin-1/DCC activates PLCγ1 through Src kinase to induce actin cytoskeleton rearrangement. Neuronal progenitor-specific knockout of Plcg1 in mice causes axon guidance defects in the dorsal part of the mesencephalon during embryogenesis. Adult Plcg1-deficient mice exhibit structural alterations in the corpus callosum, substantia innominata, and olfactory tubercle. These results suggest that PLCγ1 plays an important role in the correct development of white matter structure by mediating netrin-1/DCC signaling.

References

Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Oct 18, 1996·Cell·K Keino-MasuM Tessier-Lavigne
Jul 20, 2002·Progress in Neurobiology·André Nieoullon
Oct 21, 2004·Nature Neuroscience·Xiu-Rong RenWen-Cheng Xiong
Oct 21, 2004·Nature Neuroscience·Weiquan LiKun-Liang Guan
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fangjun Tang, Katherine Kalil
Dec 3, 2005·The Journal of Biological Chemistry·Yi XieWen-Cheng Xiong
Oct 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kafui DzirasaMiguel A L Nicolelis
Jul 3, 2008·BMB Reports·Pann-Ghill SuhSung Ho Ryu
Jan 15, 2009·Development·Sathyanath RajasekharanTimothy E Kennedy
May 14, 2010·Cold Spring Harbor Perspectives in Biology·Alain Chédotal, Linda J Richards
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colleen ManittCecilia Flores
Jun 21, 2011·Journal of Neuroscience Research·Itzel Ricaño-CornejoAlfredo Varela-Echavarría
Nov 3, 2011·Frontiers in Neuroanatomy·Katherine KalilB Ian Hutchins
Dec 29, 2011·Frontiers in Neuroscience·Hidenori AizawaHitoshi Okamoto
Aug 7, 2012·Frontiers in Cellular Neuroscience·Laetitia PrestozAfsaneh Gaillard
Oct 16, 2012·Advances in Biological Regulation·Hyun-Jun JangPann-Ghill Suh
Jan 8, 2013·Cell Reports·Katherine E HornTimothy E Kennedy
Mar 15, 2013·Trends in Neurosciences·Irina Dudanova, Rüdiger Klein
Apr 23, 2013·Developmental Biology·Shane V HegartyGerard W O'Keeffe
Nov 15, 2013·Journal of Neurophysiology·C BertramP G Overton
May 8, 2015·EMBO Reports·Mar Castillo-PaternaGuillermina López-Bendito
Oct 28, 2015·FEBS Letters·Angela AndereggRajeshwar Awatramani
Nov 10, 2015·Genes, Brain, and Behavior·G B Bissonette, M R Roesch

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Citations

Nov 20, 2018·Frontiers in Cellular Neuroscience·Erin M Craig
Feb 17, 2019·Learning & Memory·Edwin W WongTimothy E Kennedy
Dec 31, 2020·Cells·Ray Yueh Ku, Masaaki Torii
Jan 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Sung-Hyun KimJae-Yeol Joo
Mar 7, 2021·Journal of Clinical Medicine·Monika KamianowskaAnna Wasilewska
Mar 21, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yun XieDezhi Bo
Sep 24, 2020·Progress in Lipid Research·Matilda Katan, Shamshad Cockcroft
Apr 4, 2021·International Journal of Molecular Sciences·Hye Yun KimJae-Ick Kim

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