Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas

Oncotarget
Oshrat Hershkovitz-RokahStella Liberman-Aronov

Abstract

MicroRNAs (miRs) are short non-coding regulatory RNAs that control gene expression at the post-transcriptional level and play an important role in cancer development and progression, acting either as oncogenes or as tumor suppressors. Identification of aberrantly expressed miRs in patients with hematological malignancies as compared to healthy individuals has suggested that these molecules may serve as novel clinical diagnostic and prognostic biomarkers. We conducted a systematic literature review of articles published between 2007 and 2017 and re-analyzed experimentally-validated human miR expression signatures in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) from various biological sources (tumor tissue, peripheral blood, bone marrow and cell lines). A unique miR expression pattern was observed for each disease. Compared to healthy individuals, 61 miRs were aberrantly expressed in DLBCL and 85 in FL; 20-30% of aberrantly expressed miRs overlapped between the two lymphoma subtypes. Analysis of integrative positive and negative miRNA-mRNA relationships using the Ingenuity Pathway Analysis (IPA) system revealed 970 miR-mRNA pairs for DLBCL and 90 for FL. Through gene ontology analysis, we found potential reg...Continue Reading

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Citations

May 14, 2019·International Journal of Oncology·Song GaoJianping Luo
Apr 12, 2020·International Journal of Molecular Sciences·Omid KooshkakiBehzad Baradaran
Dec 3, 2020·OncoTargets and Therapy·Yan ShiShuhong Hao
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Datasets Mentioned

BETA
GSE12195

Methods Mentioned

BETA
biopsy

Software Mentioned

Bioconductor
annotate Bioconductor
UCSC XENA cancer genome browser
IPA
STRING
Ingenuity Pathway Analysis ( IPA )
miRbase
TargetScan
XENA
Gene Analytics

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