Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study.

Science Advances
S. LariviereBoris Bernhardt

Abstract

Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.

References

May 20, 2003·The European Journal of Neuroscience·Akiva S CohenDouglas A Coulter
Aug 7, 2003·Brain : a Journal of Neurology·A BernasconiD L Arnold
Feb 13, 2008·Epilepsia·Carrie R McDonaldEric Halgren
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Sep 29, 2009·Epilepsia·Angelo LabateAntonio Gambardella
Oct 5, 2011·Cerebral Cortex·Xi-Nian ZuoMichael P Milham
Mar 1, 2012·NeuroImage·D C Van EssenUNKNOWN WU-Minn HCP Consortium
Aug 25, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Mark P Richardson
Dec 20, 2012·Brain : a Journal of Neurology·Jonathan O'MuircheartaighMark P Richardson
Feb 15, 2013·Current Opinion in Neurology·Jerome EngelIstvan Mody
May 15, 2013·NeuroImage·Matthew F GlasserUNKNOWN WU-Minn HCP Consortium
Nov 16, 2013·Trends in Cognitive Sciences·Martijn P van den Heuvel, Olaf Sporns
Jul 9, 2014·Brain : a Journal of Neurology·Britta WandschneiderMatthias J Koepp
Feb 24, 2015·Nature Reviews. Neuroscience·Alex FornitoMichael Breakspear
May 27, 2016·Annals of Neurology·Boris C BernhardtNeda Bernasconi
Nov 21, 2017·NeuroImage·Jean-Philippe FortinRussell T Shinohara
Dec 15, 2017·Nature Reviews. Neuroscience·Andrea Avena-KoenigsbergerOlaf Sporns
Jan 25, 2018·Brain : a Journal of Neurology·Christopher D WhelanSanjay M Sisodiya
Jun 4, 2018·NeuroImage·Aaron F Alexander-BlochArmin Raznahan
Apr 16, 2019·Network Neuroscience·Richard F BetzelBratislav Mišić
Jul 2, 2019·JAMA Neurology·Marian GalovicMatthias J Koepp
Aug 1, 2019·Brain : a Journal of Neurology·Lorenzo CaciagliMatthias J Koepp
Dec 16, 2019·Biological Psychiatry·Golia ShafieiBratislav Mišić
May 20, 2020·Communications Biology·Yifei WengBoris C Bernhardt

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Citations

Feb 10, 2021·Epilepsy Currents·Neda Bernasconi, Irene Wang
Jul 2, 2021·Nature Methods·Sara LarivièreBoris C Bernhardt
Aug 15, 2021·NeuroImage·Jiahe ZhangSusan Whitfield-Gabrieli

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Software Mentioned

ENIGMA
SurfStat
Epilepsy
SIFT2
FMRIB
FreeSurfer
MRtrix3
ComBat

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