Network based elucidation of drug response: from modulators to targets

BMC Systems Biology
Francesco IorioDiego di Bernardo

Abstract

: Network-based drug discovery aims at harnessing the power of networks to investigate the mechanism of action of existing drugs, or new molecules, in order to identify innovative therapeutic treatments. In this review, we describe some of the most recent advances in the field of network pharmacology, starting with approaches relying on computational models of transcriptional networks, then moving to protein and signaling network models and concluding with "drug networks". These networks are derived from different sources of experimental data, or literature-based analysis, and provide a complementary view of drug mode of action. Molecular and drug networks are powerful integrated computational and experimental approaches that will likely speed up and improve the drug discovery process, once fully integrated into the academic and industrial drug discovery pipeline.

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Citations

Mar 25, 2014·BMC Systems Biology·Benjamin GarciaMichael Strong
Apr 3, 2015·Briefings in Bioinformatics·Jiao LiZhiyong Lu
Jun 19, 2015·Biochemical and Biophysical Research Communications·Mathurin DorelInna Kuperstein
Nov 8, 2014·Computational and Structural Biotechnology Journal·Bjoern TitzManuel C Peitsch
Sep 1, 2017·Public Health Genomics·Javier Perales-PatónFátima Al-Shahrour
Oct 13, 2018·Nature Reviews. Drug Discovery·Sudeep PushpakomMunir Pirmohamed
Feb 15, 2019·BMC Bioinformatics·Sunjoo BangHyunjung Shin
Sep 25, 2019·Current Drug Targets·Kening LiDong-Qing Wei
Jan 11, 2017·Briefings in Bioinformatics·Aliyu MusaFrank Emmert-Streib
Dec 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo-Min LvHong-Yu Zhang
Nov 2, 2018·Current Medicinal Chemistry·Fei WangFang-Xiang Wu

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Methods Mentioned

BETA
biopsies

Software Mentioned

SubNetwork Enrichment Analysis ( SNEA )
TSNI
IDEA
Master Regulator Analysis ( MRA )
NIR
Connectivity Map ( cMap )
cMap

Related Concepts

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