Network-centric medicine for peripheral nerve injury: Treating the whole to boost endogenous mechanisms of neuroprotection and regeneration

Neural Regeneration Research
David Romeo-Guitart, Caty Casas

Abstract

Peripheral nerve injuries caused by accidents may lead to paralysis, sensory disturbances, anaesthesia, and lack of autonomic functions. Functional recovery after disconnection of the motoneuronal soma from target tissue with proximal rupture of axons is determined by several factors: motoneuronal soma viability, proper axonal sprouting across inhibitory zones and elongation toward specific muscle, effective synapse contact rebuilding, and prevention of muscle atrophy. Therapies, such as adjuvant drugs with pleiotropic effects, that promote functional recovery after peripheral nerve injury are needed. Toward this aim, we designed a drug discovery workflow based on a network-centric molecular vision using unbiased proteomic data and neural artificial computational tools. Our focus is on boosting intrinsic capabilities of neurons for neuroprotection; this is in contrast to the common approach based on suppression of a pathobiological pathway known to be associated with disease condition. Using our workflow, we discovered neuroheal, a combination of two repurposed drugs that promotes motoneuronal soma neuroprotection, is anti-inflammatory, enhances axonal regeneration after axotomy, and reduces muscle atrophy. This drug discovery ...Continue Reading

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Citations

Apr 17, 2020·Neurourology and Urodynamics·Dora Luz Corona-QuintanillaMargarita Martínez-Gómez
Jul 2, 2020·Cells·Sara Marmolejo-Martínez-ArteseroCaty Casas
Apr 24, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·David Romeo-GuitartCaty Casas
Dec 31, 2020·Cells·Sara Marmolejo-Martínez-ArteseroCaty Casas
Aug 28, 2021·Biomedicines·Tatiana Leiva-RodríguezCaty Casas

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NeuroHeal

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