Network dynamics with BrainX(3): a large-scale simulation of the human brain network with real-time interaction

Frontiers in Neuroinformatics
Xerxes D ArsiwallaPaul F M J Verschure

Abstract

BrainX(3) is a large-scale simulation of human brain activity with real-time interaction, rendered in 3D in a virtual reality environment, which combines computational power with human intuition for the exploration and analysis of complex dynamical networks. We ground this simulation on structural connectivity obtained from diffusion spectrum imaging data and model it on neuronal population dynamics. Users can interact with BrainX(3) in real-time by perturbing brain regions with transient stimulations to observe reverberating network activity, simulate lesion dynamics or implement network analysis functions from a library of graph theoretic measures. BrainX(3) can thus be used as a novel immersive platform for exploration and analysis of dynamical activity patterns in brain networks, both at rest or in a task-related state, for discovery of signaling pathways associated to brain function and/or dysfunction and as a tool for virtual neurosurgery. Our results demonstrate these functionalities and shed insight on the dynamics of the resting-state attractor. Specifically, we found that a noisy network seems to favor a low firing attractor state. We also found that the dynamics of a noisy network is less resilient to lesions. Our si...Continue Reading

References

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Citations

Feb 26, 2016·Frontiers in Computational Neuroscience·Shouliang QiPauly Ossenblok
Jan 8, 2016·Journal of Mathematical Neuroscience·Peter AshwinRachel Nicks
Jan 7, 2016·Frontiers in Neuroinformatics·Christian NowkeTorsten W Kuhlen
Nov 21, 2015·Neural Networks : the Official Journal of the International Neural Network Society·Giovanni MaffeiPaul F M J Verschure
Jul 20, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul F M J Verschure
Jan 28, 2017·NeuroImage·Leonardo L GolloLuca Cocchi
Nov 4, 2017·The Neuroradiology Journal·Wieslaw L Nowinski
Oct 9, 2018·Network Neuroscience·Johnson J G KeirizAngus G Forbes
Jan 1, 2016·Applied Network Science·Xerxes D Arsiwalla, Paul F M J Verschure
Jul 13, 2018·Frontiers in Neuroscience·Xerxes D Arsiwalla, Paul Verschure
Mar 21, 2020·NeuroImage·Hannelore AertsDaniele Marinazzo

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Software Mentioned

BrainX
XIM
VisNEST
Kinect
Brain Connectivity Toolbox ( BCT )
MATLAB
Connectome Workbench
iqr
BrainX 3
Unity

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