Network Fingerprint of Stimulation-Induced Speech Impairment in Essential Tremor.

Annals of Neurology
Jan Niklas Petry-SchmelzerMichael T Barbe

Abstract

This study was undertaken to gain insights into structural networks associated with stimulation-induced dysarthria (SID) and to predict stimulation-induced worsening of intelligibility in essential tremor patients with bilateral thalamic deep brain stimulation (DBS). Monopolar reviews were conducted in 14 essential tremor patients. Testing included determination of SID thresholds, intelligibility ratings, and a fast syllable repetition task. Volumes of tissue activated (VTAs) were calculated to identify discriminative fibers for stimulation-induced worsening of intelligibility in a structural connectome. The resulting fiber-based atlas structure was then validated in a leave-one-out design. Fibers determined as discriminative for stimulation-induced worsening of intelligibility were mainly connected to the ipsilateral precentral gyrus as well as to both cerebellar hemispheres and the ipsilateral brain stem. In the thalamic area, they ran laterally to the thalamus and posteromedially to the subthalamic nucleus, in close proximity, mainly anterolaterally, to fibers beneficial for tremor control as published by Al-Fatly et al in 2019. The overlap of the respective clinical stimulation setting's VTAs with these fibers explained 62....Continue Reading

References

Apr 1, 1992·Journal of Neurology·H AckermannM Poremba
Dec 1, 1982·Journal of Learning Disabilities·S B Moyer
Jan 1, 1995·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·H AckermannT Hehr
Feb 17, 2000·The New England Journal of Medicine·P R SchuurmanJ D Speelman
Apr 20, 2006·Journal of Neurosurgery·Rajesh PahwaJoseph Jankovic
May 13, 2010·Stereotactic and Functional Neurosurgery·Mattias AströmKarin Wårdell
Sep 22, 2010·NeuroImage·Marco ReisertValerij Kiselev
Jun 20, 2012·Journal of Neurolinguistics·Frank H Guenther, Tony Vladusich
Nov 28, 2013·Brain : a Journal of Neurology·Sergiu GroppaJens Volkmann
Feb 18, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Elina TripolitiLudvic Zrinzo
Apr 2, 2014·Journal of Speech, Language, and Hearing Research : JSLHR·Doris MückeMartine Grice
Oct 29, 2014·IEEE Transactions on Bio-medical Engineering·Mattias AstromKarin Wardell
Jul 24, 2015·PLoS Biology·Stefan FuertingerKristina Simonyan
Nov 5, 2016·Parkinsonism & Related Disorders·Joseph Y MatsumotoBryan T Klassen
Sep 24, 2016·Brain : a Journal of Neurology·Martin M ReichIoannis U Isaias
Dec 10, 2016·Journal of Motor Behavior·Anja StaigerWolfram Ziegler
Dec 17, 2016·NeuroImage. Clinical·Till A DembekLars Timmermann
Feb 6, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Johannes BeckerLars Timmermann
Jun 7, 2017·Annals of Neurology·Andreas HornMichael D Fox
Jun 8, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Philipp MahlknechtPatricia Limousin
Oct 3, 2018·Journal of Neural Engineering·Daria Nesterovich AndersonChristopher R Butson
Feb 20, 2019·Biological Psychiatry·Juan Carlos BaldermannJens Kuhn
Aug 5, 2019·Brain : a Journal of Neurology·Bassam Al-FatlyAndrea A Kühn
Sep 10, 2019·Parkinsonism & Related Disorders·T A DembekH Treuer
Sep 26, 2019·Brain : a Journal of Neurology·Jan Niklas Petry-SchmelzerUNKNOWN EUROPAR and the IPMDS Non-Motor PD Study Group
Apr 3, 2020·Annals of Neurology·Friederike IrmenAndrea A Kühn

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