Network-level reorganisation of functional connectivity following arm amputation

NeuroImage
Tamar R MakinHeidi Johansen-Berg

Abstract

One of the most striking demonstrations of plasticity in the adult human brain follows peripheral injury, such as amputation. In the primary sensorimotor cortex, arm amputation results in massive local remapping of the missing hands' cortical territory. However, little is known about the consequences of sensorimotor deprivation on global brain organisation. Here, we used resting-state fMRI to identify large-scale reorganisation beyond the primary sensorimotor cortex in arm amputees, compared with two-handed controls. Specifically, we characterised changes in functional connectivity between the cortical territory of the missing hand in the primary sensorimotor cortex ('missing hand cortex') and two networks of interest: the sensorimotor network, which is typically strongly associated with the hand cortex, and the default mode network (DMN), which is normally dissociated from it. Functional connectivity values between the missing hand cortex and the sensorimotor network were reduced in amputees, and connectivity was weaker in individuals amputated for longer periods. Lower levels of functional coupling between the missing hand cortex and the sensorimotor network were also associated with emerged coupling of this cortex with the D...Continue Reading

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Citations

Mar 15, 2016·Frontiers in Human Neuroscience·Guangyao JiangJian Wang
Jun 15, 2015·Brain : a Journal of Neurology·Tamar R MakinIrene Tracey
Apr 20, 2016·Scientific Reports·Ting-Hsuan WuJen-Chuen Hsieh
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Mar 5, 2021·The European Journal of Neuroscience·Lingyan WangJeffrey M Yau

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Methods Mentioned

BETA
amputation

Software Mentioned

Local Analysis of Mixed Effects ( FLAME )
BET
FSL
Linear Image Registration Tool ( MCFLIRT )
FNIRT
FEAT
FMRIB Linear Image Registration Tool , FLIRT
FMRIB
Connectome Workbench

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