Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons.

Nature Neuroscience
Attila LosonczyJeffrey C Magee

Abstract

Although hippocampal theta oscillations represent a prime example of temporal coding in the mammalian brain, little is known about the specific biophysical mechanisms. Intracellular recordings support a particular abstract oscillatory interference model of hippocampal theta activity, the soma-dendrite interference model. To gain insight into the cellular and circuit level mechanisms of theta activity, we implemented a similar form of interference using the actual hippocampal network in mice in vitro. We found that pairing increasing levels of phasic dendritic excitation with phasic stimulation of perisomatic projecting inhibitory interneurons induced a somatic polarization and action potential timing profile that reproduced most common features. Alterations in the temporal profile of inhibition were required to fully capture all features. These data suggest that theta-related place cell activity is generated through an interaction between a phasic dendritic excitation and a phasic perisomatic shunting inhibition delivered by interneurons, a subset of which undergo activity-dependent presynaptic modulation.

References

Jan 1, 1986·Progress in Neurobiology·B H Bland
Jul 4, 1998·Brain Research. Brain Research Reviews·P SomogyiE H Buhl
Aug 17, 1999·Somatosensory & Motor Research·D KleinfeldS M O'Connor
Aug 18, 2000·Journal of Computational Neuroscience·A BoseM Recce
Aug 3, 2001·Nature Reviews. Neuroscience·E Salinas, T J Sejnowski
Feb 8, 2002·Neuron·György Buzsáki
Aug 27, 2002·Neuron·Frances S ChanceAlex D Reyes
Jan 16, 2003·The Journal of Physiology·Troy W Margrie, Andreas T Schaefer
May 14, 2003·Neuron·Simon J Mitchell, R Angus Silver
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Attila LosonczyZoltan Nusser
Oct 21, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas KlausbergerPeter Somogyi
Nov 3, 2005·Neural Networks : the Official Journal of the International Neural Network Society·Michael E Hasselmo, Howard Eichenbaum
Nov 23, 2006·Nature Neuroscience·David RobbeGyörgy Buzsaki
Apr 5, 2007·Nature Protocols·Joshua C GriegerR Jude Samulski
May 29, 2007·Trends in Neurosciences·Andrew P Maurer, Bruce L McNaughton
Sep 23, 1994·Science·G Laurent, H Davidowitz
Oct 9, 2007·Neuron·Tamás F Freund, István Katona
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deniz AtasoyScott M Sternson
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alipasha VaziriCharles V Shank
Oct 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David Robbe, György Buzsáki
Oct 16, 2009·Nature·Christopher D HarveyDavid W Tank
Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert SchmidtRichard Kempter
Jun 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bertalan K AndrasfalvyAlipasha Vaziri

❮ Previous
Next ❯

Citations

Jan 17, 2012·Nature Neuroscience·Matthew Lovett-BarronAttila Losonczy
Mar 27, 2012·Nature Neuroscience·Sébastien RoyerGyörgy Buzsáki
Aug 7, 2012·Nature Neuroscience·Damien LaprayThomas Klausberger
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christoph Schmidt-Hieber, Michael Häusser
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A JeewajeeN Burgess
Feb 6, 2013·PloS One·Dhanya Parameshwaran, Upinder S Bhalla
Nov 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam C WeldayHugh T Blair
May 3, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sam A BookerImre Vida
Mar 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthijs A A van der Meer, A David Redish
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin AllenHannah Monyer
Aug 9, 2011·Annual Review of Cell and Developmental Biology·Gero Miesenböck
Feb 22, 2014·Science·Matthew Lovett-BarronAttila Losonczy
Nov 18, 2014·Nature Neuroscience·John Peter RickgauerDavid W Tank
Apr 11, 2012·Journal of Neuroscience Methods·Richard KempterRobert Schmidt
Jul 16, 2015·Current Opinion in Neurobiology·Pico Caroni
Aug 9, 2011·Current Opinion in Neurobiology·Neil Burgess, John O'Keefe
Jun 4, 2011·Current Opinion in Neurobiology·Dimitri M Kullmann
Mar 5, 2011·Current Opinion in Neurobiology·Gabrielle Girardeau, Michaël Zugaro
Jun 21, 2013·Biology of the Cell·Eirini Papagiakoumou
Nov 3, 2015·Nature Neuroscience·Zev B RosenSteven A Siegelbaum
Sep 25, 2015·Neuron·Aaron D MilsteinJeffrey C Magee
Feb 22, 2012·Epilepsy & Behavior : E&B·Alex C BenderPierre-Pascal Lenck-Santini
Mar 22, 2014·Current Opinion in Neurobiology·Thomas J Younts, Pablo E Castillo
Jul 13, 2011·Neuron·Ofer YizharKarl Deisseroth
Jan 3, 2012·Current Opinion in Neurobiology·Alipasha Vaziri, Valentina Emiliani
Mar 22, 2014·Current Opinion in Neurobiology·Matthew Lovett-Barron, Attila Losonczy
Mar 15, 2015·Neurobiology of Disease·Franck KalumeWilliam A Catterall
Sep 30, 2016·Frontiers in Cellular Neuroscience·Domenico F GalatiKevin R Jones
Jun 20, 2017·Nature Neuroscience·Christoph Schmidt-HieberMichael Häusser
Jan 17, 2014·Nature·Adam Kepecs, Gordon Fishell
Jun 13, 2018·The Journal of Physiology·Reshma Basak, Rishikesh Narayanan
Jun 17, 2016·Nature Communications·Oscar HernandezValentina Emiliani
Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan
Sep 25, 2014·Journal of Neurophysiology·Allan Kjeldsen HansenMogens Andreasen
Mar 29, 2014·Nature Neuroscience·Anne CeiMichaël Zugaro
Jul 3, 2019·Frontiers in Cellular Neuroscience·Céline Drieu, Michaël Zugaro
Aug 18, 2018·Learning & Memory·Carl R Lupica, Alexander F Hoffman
Dec 3, 2010·The Journal of Physiology·Tengis Gloveli

❮ Previous
Next ❯

Software Mentioned

ImageJ
LabView
Igor Pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Caroline GeislerGyörgy Buzsáki
Neural Computation
Sandro RomaniMisha Tsodyks
Proceedings of the National Academy of Sciences of the United States of America
John Peter Rickgauer, David W Tank
© 2021 Meta ULC. All rights reserved