Network Medicine for Alzheimer's Disease and Traditional Chinese Medicine

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Juliet T JarrellXudong Huang

Abstract

Alzheimer’s Disease (AD) is a neurodegenerative condition that currently has no known cure. The principles of the expanding field of network medicine (NM) have recently been applied to AD research. The main principle of NM proposes that diseases are much more complicated than one mutation in one gene, and incorporate different genes, connections between genes, and pathways that may include multiple diseases to create full scale disease networks. AD research findings as a result of the application of NM principles have suggested that functional network connectivity, myelination, myeloid cells, and genes and pathways may play an integral role in AD progression, and may be integral to the search for a cure. Different aspects of the AD pathology could be potential targets for drug therapy to slow down or stop the disease from advancing, but more research is needed to reach definitive conclusions. Additionally, the holistic approaches of network pharmacology in traditional Chinese medicine (TCM) research may be viable options for the AD treatment, and may lead to an effective cure for AD in the future.

References

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Citations

Jan 18, 2020·International Journal of Molecular Sciences·David CohenXudong Huang
Mar 13, 2020·Translational Neuroscience·Liu Yang, Xiumin Zhao
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhuchen ZhouYuyan Zhang
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia LiZhi Sun

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MetaCore
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Cytoscape
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