Network medicine strikes a blow against breast cancer

Cell
Janine T Erler, Rune Linding

Abstract

Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

References

Jun 16, 2007·Cell·Rune LindingTony Pawson
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Paul H HuangForest M White
Feb 20, 2008·FEBS Letters·Tony Pawson, Rune Linding
Nov 19, 2009·The Journal of Pathology·Janine T Erler, Rune Linding
Jan 26, 2010·Current Opinion in Genetics & Development·Claus Jørgensen, Rune Linding

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Citations

Sep 12, 2012·Nature Biotechnology·Pau CreixellRune Linding
Dec 4, 2013·Nature Reviews. Genetics·Mete Civelek, Aldons J Lusis
Feb 5, 2014·Future Oncology·Georgios D LianosDimitrios H Roukos
Aug 13, 2013·Pharmacogenomics·Dimitrios H Roukos
Apr 4, 2013·Biomarkers in Medicine·Christos S KatsourasLampros K Michalis
Oct 30, 2014·The New England Journal of Medicine·Donal P McLornanGhulam J Mufti
Aug 21, 2012·Cellular and Molecular Life Sciences : CMLS·Miguel Ángel Medina
Jul 31, 2013·Expert Review of Molecular Diagnostics·Dimitrios H RoukosGeorge Baltogiannis
Apr 12, 2013·Expert Review of Proteomics·Dimitrios H RoukosLampros K Michalis
Nov 13, 2012·Expert Opinion on Drug Discovery·Nagasuma Chandra, Jyothi Padiadpu
Oct 11, 2014·Proteomics·Serhiy Havrylov, Morag Park
Jun 12, 2013·The FEBS Journal·Zexian LiuYu Xue
Dec 18, 2013·Proteomics·Jianxin WangFang-Xiang Wu
Apr 12, 2016·Nature Reviews. Endocrinology·Kaixin ZhouEwan R Pearson
Nov 21, 2012·New Biotechnology·Pier Federico Gherardini, Manuela Helmer-Citterich
Dec 3, 2014·Biochimica Et Biophysica Acta·Mari Masuda, Tesshi Yamada
Mar 29, 2014·Methods : a Companion to Methods in Enzymology·Andrew E TeschendorffReimer Kuehn
Sep 12, 2014·PLoS Computational Biology·Alex J Cornish, Florian Markowetz
Sep 25, 2016·BMC Systems Biology·David MurrugarraReinhard Laubenbacher
Jan 21, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Tamas KorcsmarosGiulio Superti-Furga
Jan 12, 2016·EURASIP Journal on Bioinformatics & Systems Biology·David Murrugarra, Elena S Dimitrova
Feb 21, 2018·European Journal of Clinical Investigation·Paul Perco, Gert Mayer
Mar 4, 2015·Perspectives in Medicinal Chemistry·Hailin ZhengMoussa Youdim
Oct 3, 2013·International Journal of Oncology·Hyunjeong SeoBuhyun Youn
May 3, 2019·PloS One·Mohammad MoradiMohammad-Hadi Foroughmand-Araabi
May 11, 2019·Biology Direct·Maarten LarmuseauKathleen Marchal

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