Network meta-analysis: a technique to gather evidence from direct and indirect comparisons

Pharmacy Practice
Fernanda S ToninRoberto Pontarolo

Abstract

Systematic reviews and pairwise meta-analyses of randomized controlled trials, at the intersection of clinical medicine, epidemiology and statistics, are positioned at the top of evidence-based practice hierarchy. These are important tools to base drugs approval, clinical protocols and guidelines formulation and for decision-making. However, this traditional technique only partially yield information that clinicians, patients and policy-makers need to make informed decisions, since it usually compares only two interventions at the time. In the market, regardless the clinical condition under evaluation, usually many interventions are available and few of them have been studied in head-to-head studies. This scenario precludes conclusions to be drawn from comparisons of all interventions profile (e.g. efficacy and safety). The recent development and introduction of a new technique - usually referred as network meta-analysis, indirect meta-analysis, multiple or mixed treatment comparisons - has allowed the estimation of metrics for all possible comparisons in the same model, simultaneously gathering direct and indirect evidence. Over the last years this statistical tool has matured as technique with models available for all types o...Continue Reading

Citations

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Sep 14, 2018·International Journal of Epidemiology·Fernanda S ToninFernando Fernandez-Llimos
Feb 21, 2018·European Child & Adolescent Psychiatry·Sarah C O S PadilhaRoberto Pontarolo
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Software Mentioned

MCMCpack
JAGS
GeMTC
R
STATA
WinBUGS
PRISMA
LaplacesDemon
NMA
R Studio

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