Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients

Journal of Translational Medicine
Ákos TényiJosep Roca

Abstract

Chronic obstructive pulmonary disease (COPD) patients often show skeletal muscle dysfunction that has a prominent negative impact on prognosis. The study aims to further explore underlying mechanisms of skeletal muscle dysfunction as a characteristic systemic effect of COPD, potentially modifiable with preventive interventions (i.e. muscle training). The research analyzes network module associated pathways and evaluates the findings using independent measurements. We characterized the transcriptionally active network modules of interacting proteins in the vastus lateralis of COPD patients (n = 15, FEV1 46 ± 12% pred, age 68 ± 7 years) and healthy sedentary controls (n = 12, age 65 ± 9  years), at rest and after an 8-week endurance training program. Network modules were functionally evaluated using experimental data derived from the same study groups. At baseline, we identified four COPD specific network modules indicating abnormalities in creatinine metabolism, calcium homeostasis, oxidative stress and inflammatory responses, showing statistically significant associations with exercise capacity (VO2 peak, Watts peak, BODE index and blood lactate levels) (P < 0.05 each), but not with lung function (FEV1). Training-induced networ...Continue Reading

Associated Clinical Trials

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Citations

Jan 19, 2019·Journal of Cachexia, Sarcopenia and Muscle·Anita E M KneppersAnnemie M W J Schols
Nov 28, 2019·Journal of Applied Physiology·Joseph BalnisAriel Jaitovich
Dec 18, 2020·Frontiers in Oncology·Gioacchino P MarcecaCarlo M Croce
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dulce Peris-MorenoDaniel Taillandier

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Methods Mentioned

BETA
Chips
biopsies
carbonylation

Software Mentioned

COPD
Gene Set Analysis
Healthy
TE
HotNet2

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