Network neuroscience of apathy in cerebrovascular disease.

Progress in Neurobiology
Jonathan TayHugh S Markus

Abstract

Apathy is a reduction in motivated goal-directed behavior (GDB) that is prevalent in cerebrovascular disease, providing an important opportunity to study the mechanistic underpinnings of motivation in humans. Focal lesions, such as those seen in stroke, have been crucial in developing models of brain regions underlying motivated behavior, while studies of cerebral small vessel disease (SVD) have helped define the connections between brain regions supporting such behavior. However, current lesion-based models cannot fully explain the neurobiology of apathy in stroke and SVD. To address this, we propose a network-based model which conceptualizes apathy as the result of damage to GDB-related networks. A review of the current evidence suggests that cerebrovascular disease-related pathology can lead to network changes outside of initially damaged territories, which may propagate to regions that share structural or functional connections. The presentation and longitudinal trajectory of apathy in stroke and SVD may be the result of these network changes. Distinct subnetworks might support cognitive components of GDB, the disruption of which results in specific symptoms of apathy. This network-based model of apathy may open new approac...Continue Reading

Citations

Jul 12, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Jonathan TayHugh S Markus
Feb 3, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Jonathan TayHugh S Markus
Feb 18, 2021·International Journal of Geriatric Psychiatry·Elzbieta Klimiec-MoskalTomasz Dziedzic
Feb 24, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Anna Maria LopatkiewiczTomasz Dziedzic
Apr 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mario Fahed, David C Steffens
Jul 13, 2021·Frontiers in Aging Neuroscience·Jung Yun JangDaniel A Nation

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