PMID: 8962152Dec 10, 1996Paper

Network of tangential pathways for neuronal migration in adult mammalian brain

Proceedings of the National Academy of Sciences of the United States of America
Fiona Doetsch, Arturo Alvarez-Buylla

Abstract

Cells in the brains of adult mammals continue to proliferate in the subventricular zone (SVZ) throughout the lateral wall of the lateral ventricle. Here we show, using whole mount dissections of this wall from adult mice, that the SVZ is organized as an extensive network of chains of neuronal precursors. These chains are immunopositive to the polysialylated form of NCAM, a molecule present at sites of plasticity, and TuJ1, an early neuronal marker. The majority of the chains are oriented along the rostrocaudal axis and many join the rostral migratory stream that terminates in the olfactory bulb. Using focal microinjections of DII and transplantation of SVZ cells carrying a neuron-specific reporter gene, we demonstrate that cells originating at different rostrocaudal levels of the SVZ migrate rostrally and reach the olfactory bulb where they differentiate into neurons. Our results reveal an extensive network of pathways for the tangential chain migration of neuronal precursors throughout the lateral wall of the lateral ventricle in the adult mammalian brain.

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Citations

Aug 26, 1998·Journal of Neurobiology·J M García-VerdugoA Alvarez-Buylla
Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·C A Walsh
Jun 28, 2000·The Journal of Comparative Neurology·C S WeickertJ E Kleinman
Nov 26, 2002·Annals of Neurology·Jack M ParentDonna M Ferriero
Dec 4, 2002·Journal of Cellular Biochemistry·James E Goldman
Sep 3, 2002·Journal of Neuroscience Research·Stanley TamakiNobuko Uchida
Oct 9, 2007·Cell and Tissue Research·Joanne C Conover, Ryan Q Notti
Feb 11, 2012·Cell and Tissue Research·Janusz J JadaszPatrick Küry
Jan 3, 2006·Cellular and Molecular Neurobiology·Barbora MitruskováEnikö Raceková
Apr 25, 2006·Cellular and Molecular Neurobiology·Marcela MartoncíkováJudita Orendácová
May 10, 2007·Current Neurology and Neuroscience Reports·Georgia Panagiotakos, Viviane Tabar
Feb 16, 2010·Journal of Molecular Neuroscience : MN·Yu Wang, Aviva J Symes
Oct 6, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Abdellatif Benraiss, Steven A Goldman
Apr 6, 2004·Brain Research·Melissa J McGinnRaymond J Colello
Aug 23, 2005·Brain Research. Brain Research Reviews·Esperanza R MatarredonaCarmen Estrada
May 26, 2005·Progress in Neurobiology·Jason G EmsleyJeffrey D Macklis
Apr 12, 2002·Brain Research. Developmental Brain Research·Sanjay S Magavi, Jeffrey D Macklis
Oct 2, 2003·Brain Research. Developmental Brain Research·Soo Kyung KangJin Sup Jung
Apr 8, 1998·Trends in Neurosciences·S A Goldman, M B Luskin
Mar 15, 2003·Progress in Neurobiology·Christine Y BrazelSteven W Levison
May 29, 2002·Brain Research Bulletin·Jose Manuel García-VerdugoEnrique Font
May 29, 2002·Brain Research Bulletin·Arturo Alvarez-BuyllaFiona Doetsch
May 29, 2002·Brain Research Bulletin·Fernando Nottebohm
Jan 25, 2003·Experimental Gerontology·Paola ArlottaJeffrey D Macklis
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Magdi M Sobeih, Gabriel Corfas

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