Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction

Bioscience Reports
Xiaowei NiuZheng Zhang

Abstract

Background: To decipher the mechanisms of Angelica sinensis for the treatment of acute myocardial infarction (AMI) using network pharmacology analysis. Methods: Databases were searched for the information on constituents, targets, and diseases. Cytoscape software was used to construct the constituent-target-disease network and screen the major targets, which were annotated with the DAVID (Database for Annotation, Visualization and Integrated Discovery) tool. The cardioprotective effects of Angelica sinensis polysaccharide (ASP), a major component of A. sinensis, were validated both in H9c2 cells subjected to simulated ischemia by oxygen and glucose deprivation and in rats with AMI by ligation of the left anterior coronary artery. Results: We identified 228 major targets against AMI injury for A. sinensis, which regulated multiple pathways and hit multiple targets involved in several biological processes. ASP significantly decreased endoplasmic reticulum (ER) stress-induced cell death both in vitro and in vivo In ischemia injury rats, ASP treatment reduced infarct size and preserved heart function. ASP enhanced activating transcription factor 6 (ATF6) activity, which improved ER-protein folding capacity. ASP activated the expres...Continue Reading

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Citations

Apr 30, 2020·Plastic and Reconstructive Surgery·Amy S XueRod J Rohrich
Apr 4, 2019·Chinese Journal of Integrative Medicine·Ting-Ting LuoJiao Guo
Oct 21, 2019·Chinese Journal of Integrative Medicine·Yuan-Yue LiuLei Sheng
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Aug 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Cong WangHao Yu

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Methods Mentioned

BETA
protein folding
flow cytometry
coronary artery ligation
ELISA
protein assay
MDA
transfection

Software Mentioned

Cytoscape
TCM
CytoNCA
DAVID ( Database for Annotation , Visualization and Integrated...
BATMAN
GraphPad
Bisogenet
PolySearch2
Mesh
TCMSP

Related Concepts