Network pharmacology-based research on the active component and mechanism of the antihepatoma effect of Rubia cordifolia L

Journal of Cellular Biochemistry
Yiyi XiongMeide Zhang

Abstract

Rubia cordifolia L. is widely used in Asia and its antihepatoma effect has been proved by in vitro and in vivo experiments. However, there are few studies on its specific mechanism. In the present study, the network pharmacology method was used to construct the component/target/pathway molecular regulatory network for the antihepatoma effect of Rubia cordifolia L. to explore the effective components of Rubia cordifolia L. and its potential mechanism. The chemical components of Rubia cordifolia L. were identified through literature and databases, and the components were evaluated and screened by drug likeness and pharmacokinetic characteristics (ADMET). The targets of active components were predicted according to the reverse pharmacophore matching model. The hepatic carcinoma-related genes were found in databases, and antihepatoma-related gene targets were selected through comparison. The functions of target genes and related pathways were analyzed and screened using the Database for Annotation, Visualization and Integrated Discovery, and the component/target/pathways network of antihepatoma effect of Rubia cordifolia L. was constructed using Cytoscape software. Finally, 16 active compounds were screened from Rubia cordifolia L....Continue Reading

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Citations

May 30, 2020·Biomolecules·Eva María Domínguez-MartínAna María Díaz-Lanza
May 30, 2020·Current Microbiology·Chuansheng LiuShaohua Wu
Oct 16, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Kun Xia HuXiao Song
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Manyuan XuWeiguo Sun

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