Network pharmacology-based therapeutic mechanism of Kuanxiong aerosol for angina pectoris.

Journal of Ethnopharmacology
Bihan WuPintong Huang

Abstract

Kuanxiong aerosol has been reported to be an effective and safe clinical treatment for angina pectoris (AP). To explore the potential pharmacological mechanism of Kuanxiong aerosol by combined methods of network pharmacology prediction and experimental verification. Networks of Kuanxiong aerosol-associated targets and AP-related genes were constructed through STRING database. Potential targets and pathway enrichment analysis related to the therapeutic efficacy of Kuanxiong aerosol were identified using Cytoscape and Database for Annotation, Visualization and Integrated Discovery (DAVID). To explore the mechanism of action of Kuanxiong aerosol, its in vitro effects on myocardial hypoxia, inflammatory cytokines, and oxidative injury, and its in vivo pharmacological effects on myocardial ischemia and cardiac fibrosis were studied in rat models. Network pharmacology analysis revealed that the potential targets mainly include the Fas ligand (FASLG), interleukin 4 (IL4), and catalase (CAT), which mediated the processes of apoptosis, and cellular responses to hypoxia, lipopolysaccharide (LPS), reactive oxygen species (ROS), and mechanical stimulus. Multiple pathways, such as the hypoxia-inducible factor 1 (HIF1) and tumor necrosis fac...Continue Reading

References

Apr 6, 2000·Journal of Applied Physiology·G L Semenza
Feb 19, 2002·Journal of the American College of Cardiology·Masumi ShimizuToshio Ogihara
Mar 9, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lalita A BharadwajNick Ovsenek
Feb 25, 2003·British Journal of Pharmacology·Péter Ferdinandy, Richard Schulz
Mar 11, 2003·The Journal of Pharmacy and Pharmacology·Kozo YaoTetsuji Ohno
Feb 14, 2004·Medical Hypotheses·Jian-Jun Li
Sep 29, 2004·Journal of Clinical Pathology·A E Greijer, E van der Wall
Aug 11, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·B-S ParkS-E Lee
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Apr 28, 2010·Biochemical and Biophysical Research Communications·Toshihiko AkiKoichi Uemura
Jul 20, 2012·Canadian Journal of Physiology and Pharmacology·Subir Kumar MaulikSandeep Seth
Apr 17, 2014·Journal of Cheminformatics·Jinlong RuLing Yang
Aug 30, 2014·International Journal of Medical Sciences·Cui-Ying MaoPing Yang
Apr 8, 2015·Journal of Physiology and Biochemistry·Sarita NehraDeepika Saraswat
Jul 3, 2015·European Journal of Pharmacology·Zahra Zeraatpisheh, Jafar Vatanparast
Dec 17, 2015·The Journal of Pharmacology and Experimental Therapeutics·Gavin E JarvisAndrew J Thompson
Apr 9, 2016·Journal of Basic and Clinical Pharmacy·Anroop B Nair, Shery Jacob
Nov 14, 2017·Natural Product Research·Ajay BommareddyChandradhar Dwivedi
Nov 11, 2018·BMC Pharmacology & Toxicology·Qiang LuoHongjing Guan
Apr 19, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·Roberto FerrariCristina Balla

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