Network properties of the dentate gyrus in epileptic rats with hilar neuron loss and granule cell axon reorganization

Journal of Neurophysiology
P S Buckmaster, F E Dudek

Abstract

Neuron loss in the hilus of the dentate gyrus and granule cell axon reorganization have been proposed as etiologic factors in human temporal lobe epilepsy. To explore these possible epileptogenic mechanisms, electrophysiological and anatomic methods were used to examine the dentate gyrus network in adult rats that had been treated systemically with kainic acid. All kainate-treated rats, but no age-matched vehicle-treated controls, were observed to have spontaneous recurrent motor seizures beginning weeks to months after exposure to kainate. Epileptic kainate-treated rats and control animals were anesthetized for field potential recording from the dentate gyrus in vivo. Epileptic kainate-treated rats displayed spontaneous positivities ("dentate electroencephalographic spikes") with larger amplitude and higher frequency than those in control animals. After electrophysiological recording, rats were perfused and their hippocampi were processed for Nissl and Timm staining. Epileptic kainate-treated rats displayed significant hilar neuron loss and granule cell axon reorganization. It has been hypothesized that hilar neuron loss reduces lateral inhibition in the dentate gyrus, thereby decreasing seizure threshold. To assess lateral in...Continue Reading

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Citations

May 20, 2003·The European Journal of Neuroscience·Akiva S CohenDouglas A Coulter
Apr 20, 2007·Journal of Neurophysiology·Ben NahirCharles J Frazier
Nov 16, 2010·Physical Biology·Casey M Schneider-MizellLeonard M Sander
Sep 1, 2012·The European Journal of Neuroscience·Paulette A McRaeBrenda E Porter
Mar 15, 2001·Journal of Neurophysiology·J P Wuarin, F E Dudek
Aug 17, 2004·Epilepsy Currents·F Edward Dudek
Feb 26, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Markus M LindroosIrma E Holopainen
Jul 1, 2005·Epilepsia·João Pereira LeiteJorge Eduardo Moreira
Mar 19, 2005·The Journal of Comparative Neurology·Sung-Eun KwakTae-Cheon Kang
Feb 26, 2008·Epilepsia·Luciana Patrízia A Andrade-ValençaJoão Pereira Leite
Dec 6, 2002·Journal of Neurophysiology·Michael V BarattaMelanie K Tallent
Apr 29, 1998·Current Opinion in Neurology·J G Jefferys
Sep 22, 2000·Epilepsia·I BlümckeO D Wiestler
Aug 7, 2002·Journal of Neurophysiology·Michael S Jones, Daniel S Barth
Jan 12, 2001·Journal of Neurophysiology·B N Smith, F E Dudek
Jul 16, 2004·Journal of Neurophysiology·Adolfo E Talpalar, Yoram Grossman
Jul 22, 2010·Epilepsia·Ricardo Mario AridaEsper Abrão Cavalheiro
Oct 6, 2004·Epilepsia·Philip A WilliamsF Edward Dudek
Nov 9, 2000·Journal of Neurophysiology·J L HardisonJ V Nadler

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