Network science meets respiratory medicine for OSAS phenotyping and severity prediction

PeerJ
Stefan MihaicutaLucretia Udrescu

Abstract

Obstructive sleep apnea syndrome (OSAS) is a common clinical condition. The way that OSAS risk factors associate and converge is not a random process. As such, defining OSAS phenotypes fosters personalized patient management and population screening. In this paper, we present a network-based observational, retrospective study on a cohort of 1,371 consecutive OSAS patients and 611 non-OSAS control patients in order to explore the risk factor associations and their correlation with OSAS comorbidities. To this end, we construct the Apnea Patients Network (APN) using patient compatibility relationships according to six objective parameters: age, gender, body mass index (BMI), blood pressure (BP), neck circumference (NC) and the Epworth sleepiness score (ESS). By running targeted network clustering algorithms, we identify eight patient phenotypes and corroborate them with the co-morbidity types. Also, by employing machine learning on the uncovered phenotypes, we derive a classification tree and introduce a computational framework which render the Sleep Apnea Syndrome Score (SASScore); our OSAS score is implemented as an easy-to-use, web-based computer program which requires less than one minute for processing one individual. Our eva...Continue Reading

References

Oct 3, 1999·Annals of Internal Medicine·N C NetzerK P Strohl
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Terry YoungDaniel J Gottlieb
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·M Girvan, M E J Newman
Jan 22, 2004·Nature Reviews. Genetics·Albert-László Barabási, Zoltán N Oltvai
Jan 24, 2004·The European Respiratory Journal·N Pelletier-FleuryJ L Racineux
Sep 27, 2005·Sleep Medicine Reviews·Anna Tessa C VillaneuvaRonald R Grunstein
Nov 12, 2005·The New England Journal of Medicine·H Klar YaggiVahid Mohsenin
Jan 2, 2007·The European Respiratory Journal·W T McNicholasUNKNOWN Management Committee of EU COST ACTION B26
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kwang-Il GohAlbert-László Barabási
Jul 27, 2007·The New England Journal of Medicine·Albert-László Barabási
Oct 9, 2007·Nature Biotechnology·Muhammed A YildirimMarc Vidal
Jan 30, 2008·Cell Research·Jing-Dong Jackie Han
Feb 6, 2008·Proceedings of the American Thoracic Society·Naresh M Punjabi
Apr 24, 2008·Anesthesiology·Frances ChungColin M Shapiro
Apr 28, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andreas Noack
Jun 1, 2008·Expert Review of Respiratory Medicine·Won LeeBabak Mokhlesi
Mar 19, 2011·Cell·Marc VidalAlbert-László Barabási
Apr 19, 2011·Sleep & Breathing = Schlaf & Atmung·Itay E Gabbay, Peretz Lavie
May 31, 2011·The European Respiratory Journal·J HednerJ Zielinski
Aug 19, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Simon A JoostenGarun Hamilton
Oct 18, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Robert J FarneyJames M Walker
Oct 18, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Graciela E SilvaStuart F Quan
Dec 3, 2011·Journal of Sleep Research·Jürgen FischerUNKNOWN Board of the European Sleep Research Society (ESRS), Regensburg, Germany
Feb 9, 2012·PloS One·Rogerio Santos-SilvaLia Rita Azeredo Bittencourt
Jun 16, 2012·The European Respiratory Journal·Karri T UtriainenTimo T Laitio
Sep 20, 2012·Current Opinion in Pulmonary Medicine·Frank M Ralls, Madeleine Grigg-Damberger
Dec 5, 2012·Chest·Sibyl Simon, Nancy Collop
Dec 22, 2012·The European Respiratory Journal·Valentina A RossiMalcolm Kohler
Apr 17, 2013·American Journal of Epidemiology·Paul E PeppardKhin Mae Hla
Jun 21, 2013·The New England Journal of Medicine·Stavros G MemtsoudisMadhu Mazumdar
Jul 25, 2013·Molecular & Cellular Proteomics : MCP·Amitabh SharmaAlbert-László Barabási
Dec 11, 2013·The Lancet. Respiratory Medicine·Manuel Sánchez-de-la-TorreFerran Barbé
Dec 11, 2013·The Lancet. Respiratory Medicine·Jessie P BakkerAtul Malhotra
Jul 27, 2014·The European Respiratory Journal·Rosa FanerAlvar Agustí
Aug 22, 2014·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Frances ChungPu Liao
Sep 5, 2014·The European Respiratory Journal·Lichuan YeThorarinn Gislason
Sep 26, 2014·American Journal of Respiratory and Critical Care Medicine·Diego DiezCraig E Wheelock
Jul 15, 2015·The European Respiratory Journal·Miguel J DivoUNKNOWN BODE Collaborative Group
Sep 15, 2015·Journal of Sleep Research·George D VavougiosKonstantinos I Gourgoulianis
Jan 1, 2015·Nature Reviews. Disease Primers·Patrick LévyJean-Louis Pépin
Jun 21, 2016·The Lancet. Respiratory Medicine·Helena Marti-SolerRaphael Heinzer
Jul 16, 2016·Nature and Science of Sleep·Alyssa CairnsRichard Bogan

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Citations

Oct 27, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Maria R BonsignoreJosep M Montserrat
May 29, 2018·Experimental and Therapeutic Medicine·Jidong ZhangWenzhong Zhang
Jan 30, 2021·Frontiers in Physiology·Antonio Barajas-MartínezAna Leonor Rivera
Dec 9, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Darren R Mansfield
Dec 17, 2020·Journal of Clinical Medicine·Alexandru TopîrceanuStefan Mihaicuta
Apr 27, 2021·Frontiers in Cardiovascular Medicine·Jin ChenYiming Zeng
May 1, 2021·Medicina·Karolina CharčiūnaitėRolandas Zablockis
May 29, 2021·Frontiers in Physiology·Antonio Barajas-MartínezAna Leonor Rivera

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Software Mentioned

STOP
R Studio
BANG
Gephi
R
SAS
Force Atlas

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