PMID: 6971876May 1, 1981Paper

Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus

The Journal of Clinical Investigation
N I AbdouT Suzuki

Abstract

Regulation of serum anti-DNA antibody in systemic lupus erythematosus (SLE) by an antiidiotypic antibody was evaluated. Various sera from SLE patients in active and inactive states of their disease, as well as sera from normal individuals, were first completely depleted of anti-DNA and of DNA by affinity chromatography. The suppressive capacity of equimolar concentrations of the various depleted sera (blocking sera) on target lupus sera were determined. The target sera were from lupus patients with known DNA-binding capacity. Blocking sera from inactive SLE suppressed the binding of autologous anti-DNA antibody to [(3)H]DNA (n = 19,P < 0.01). Blocking sera from active SLE (n = 19), as well as human serum albumin, did not suppress. Sera from normal donors who had no contact with lupus patients or with lupus sera did not suppress (n = 14, P > 0.5), whereas those from normal donors who had contact with lupus patients or sera did suppress the binding (n = 5,P < 0.02). The anti-anti-DNA antibody suppressive activity in the inactive lupus serum was shown to be localized within the F(ab')(2) portion of immunoglobulin (Ig)G and could not be removed upon adsorption by normal human gammaglobulin. Furthermore, immune complexes could be de...Continue Reading

Citations

Jan 1, 1990·Current Eye Research·Y de Kozak
Jan 1, 1989·Journal of Clinical Immunology·N I AbdouK M Hassanein
Jul 23, 1987·The New England Journal of Medicine·S Burdette, R S Schwartz
Jun 1, 1989·Journal of Cellular Biochemistry·E MozesS Mendlovic
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S C JordanR N Fine
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A TsubouchiS Kakumu
Aug 30, 1984·The New England Journal of Medicine·M Zouali, A Eyquem
Jan 1, 1983·Springer Seminars in Immunopathology·M GoldmanP H Lambert
Jan 1, 1983·Annals of the New York Academy of Sciences·M Zanetti
Jan 1, 1997·Lupus·J Gavalchin, N A Staines
Feb 1, 1991·Australian and New Zealand Journal of Medicine·J A Savige, C M Lockwood
Oct 1, 1988·Immunological Reviews·M ZoualiR S Schwartz
Nov 1, 1985·Journal of Clinical Immunology·N I Abdou
Oct 18, 1984·The New England Journal of Medicine·Y Shoenfeld, R S Schwartz
Jan 1, 1986·Annals of the New York Academy of Sciences·P E Bigazzi
Jan 1, 1989·International Reviews of Immunology·M D KazatchkineU Nydegger
Jan 1, 1997·Arthritis and Rheumatism·R C WilliamsF Silvestris
Jan 1, 1983·Springer Seminars in Immunopathology·I M RoittP M Lydyard
Jan 1, 1990·International Reviews of Immunology·R Attanasio, R C Kennedy
Jul 1, 1992·Journal of Veterinary Internal Medicine·E Miller
Feb 1, 1991·European Journal of Immunology·M Zöller, M Achtnich
Jan 9, 1992·The New England Journal of Medicine·J M Dwyer
May 1, 1986·Immunological Investigations·M Zanetti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.