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Neu-p11 induces NLRP3 inflammasome-induced pyroptosis via provoking NOX4-mediated mitochondrial oxidative injury in chordoma cells

bioRxiv

Feb 13, 2020

Shutian Zhang

Abstract

Chordoma is a rarely malignant bone tumor with highly resistance to radiotherapy and chemotherapy. Melatonin has been shown to inhibit tumor cell invasion, metastasis and induce apoptosis in several types of cancer. Activation of melatonin receptor inhibit cancer stemness of chordoma, w...read more

Mentioned in this Paper

Chordoma
Apoptosis
NOX4 protein, human
Melatonin Receptors
Detected (Finding)
SIRT3 protein, human
NADPH Oxidase 4
Cell Invasion
Membrane
Antioxidants
1
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Pharmacological Research : the Official Journal of the Italian Pharmacological Society

NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats

Pharmacological Research : the Official Journal of the Italian Pharmacological SocietyMay 12, 2009
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Neu-p11 induces NLRP3 inflammasome-induced pyroptosis via provoking NOX4-mediated mitochondrial oxidative injury in chordoma cells

bioRxiv

Feb 13, 2020

Shutian Zhang

DOI: 10.1101/2020.02.12.946665

Abstract

Chordoma is a rarely malignant bone tumor with highly resistance to radiotherapy and chemotherapy. Melatonin has been shown to inhibit tumor cell invasion, metastasis and induce apoptosis in several types of cancer. Activation of melatonin receptor inhibit cancer stemness of chordoma, w...read more

Mentioned in this Paper

Chordoma
Apoptosis
NOX4 protein, human
Melatonin Receptors
Detected (Finding)
SIRT3 protein, human
NADPH Oxidase 4
Cell Invasion
Membrane
Antioxidants
1

Feeds With Similar Papers

ROS & Mitochondria

Reactive oxygen species can be generated during mitochondrial processes including oxidative phosphorylation and can contribute to DNA damage. Here is the latest research on ROS and mitochondria.

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society

NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats

Pharmacological Research : the Official Journal of the Italian Pharmacological SocietyMay 12, 2009
Meihua SheWeidong Yin
Paper Details
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