NeuAc alpha 2,3gal-glycoconjugate expression determines cell susceptibility to the porcine rubulavirus LPMV

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
J Reyes-LeyvaE Zenteno

Abstract

Relevance of membrane sialoglycoconjugates as receptors for infection by the porcine rubulavirus has been determined in vitro by sugar and lectin competition assays and by inhibition of glycosylation. Our results show that NeuAc alpha 2,3Gal but not NeuAc alpha 2,6Gal inhibits the virus infectivity of Vero cells, and the virus was effectively blocked with the lectin Maackia amurensis, specific for NeuAc alpha 2,3Gal. Inhibition of the cellular glycosylation with tunicamycin, deoxinojirimycin as well as neuraminidase treatment diminishes the viral capacity to bind and infect this cell line. Dexamethasone, which promotes the activity of sialyl alpha 2,6 glycosyltransferase, also diminishes the cell susceptibility for infection. This is the first report confirming that NeuAc alpha-2,3Gal recognition is determinant in the pathogenesis of the porcine rubulavirus.

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Citations

Mar 25, 2004·Protein Expression and Purification·Gerardo Santos-LópezJulio Reyes-Leyva
Jun 8, 2001·Veterinary Immunology and Immunopathology·J HernándezE Zenteno
Oct 9, 1998·Veterinary Immunology and Immunopathology·J HernándezE Zenteno
Sep 28, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·V VallejoE Zenteno
Sep 28, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·C SierraL Vázquez
Jun 19, 2013·Virus Research·José Francisco Rivera-BenitezHumberto Ramírez-Mendoza
Nov 21, 2015·Infection Ecology & Epidemiology·Julieta Sandra Cuevas-RomeroMikael Berg
Nov 7, 2008·Veterinary Immunology and Immunopathology·J Sandra CuevasPablo Hernández-Jáuregui
Jan 21, 2017·Virus Research·Jenifer HerreraJosé Francisco Rivera-Benítez
May 16, 2017·Research in Veterinary Science·Gerardo Santos-LópezIrma Herrera-Camacho

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