Neuhauser lecture. Reflux nephropathy: a personal historical review

AJR. American Journal of Roentgenology
C J Hodson

Abstract

High pressure reflux may be a major cause of chronic renal failure both with and without associated urinary tract infection. The concept of reflux nephropathy includes not only the entity previously known as "chronic atrophic pyelonephritis," but other forms of renal disease such as the Ask-Upmark kidney, renal segmental hypoplasia, and the generalized changes that resemble those of obstructive nephropathy but which are secondary to reflux. Lobar and papillary anatomic variations play an important role in predisposing certain kidneys or parts of a kidney to damage from high pressure reflux, with or without infection. Prolonged high pressure sterile reflux can not only cause focal scarring in papillae susceptible to intrarenal reflux, but can cause the conversion of nonsusceptible papillae, so that scarring may then become generalized. The mechanisms of scar production induced by intrarenal reflux remain unclear, but mechanical immunologic, bacterial, and vascular factors are current subjects of investigation. There is mounting evidence that it is in infancy that a train of events starts which culminates in this renal damage and that much of this may be well under way quite early in childhood and remain clinically undetected unt...Continue Reading

Citations

Oct 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H Olbing
Dec 1, 1995·European Journal of Nuclear Medicine·H R Nadel
Jan 1, 1987·Pediatric Radiology·F DiardS Bernard
Jan 1, 1986·Urologic Radiology·L SirotaH Boichis
Jul 1, 1986·Seminars in Roentgenology·R C PfisterI C Yoder
Jan 1, 1985·Clinical Radiology·J P OwenD N Kerr
Dec 1, 1989·British Journal of Urology·D C HanburyP Farman
Jan 1, 1986·Archives of Disease in Childhood·D Lindsell, M Moncrieff
Dec 1, 1986·Archives of Disease in Childhood·G B Haycock
Jan 1, 1985·Upsala Journal of Medical Sciences·K ClaessonL E Lörelius
Jan 1, 1985·Urology·N J BakkerR J Scholtmeijer
Apr 1, 1983·British Journal of Urology·P M Cavanagh, T Sherwood
Jul 1, 1992·The Journal of Infection·A I Airede
Oct 7, 2004·BMC Nephrology·Guy H NeildChristopher R J Woodhouse
Mar 17, 1984·British Medical Journal·C G Fairburn, P J Cooper
Dec 4, 2012·Expert Review of Anti-infective Therapy·Maria Bitsori, Emmanouil Galanakis
Aug 10, 2000·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·A L DalmoseM M Swindle
Nov 21, 2017·Urolithiasis·Palle J S Osther
Nov 1, 1985·The Journal of Urology·G F Steinhardt
Nov 12, 2015·Current Opinion in Urology·Palle J S OstherHelene U Jung
Jun 20, 2018·World Journal of Urology·Theodoros TokasUNKNOWN Training and Research in Urological Surgery and Technology (T.R.U.S.T.)-Group
Feb 27, 2021·Journal of Ultrasound·Andrea Cvitkovic-RoicGoran Roic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.