Neural activation-based sexual orientation and its correlation with free testosterone level in postoperative female-to-male transsexuals: preliminary study with 3.0-T fMRI

Surgical and Radiologic Anatomy : SRA
Gwang-Won KimGwang-Woo Jeong

Abstract

The purpose of this study was to evaluate the brain activation pattern associated with sexual orientation and its correlation with the level of the free testosterone (free T) in postoperative female-to-male (FtM) transsexuals using a 3.0-Tesla functional magnetic resonance imaging (fMRI). Eleven postoperative FtM transsexuals with sex reassignment surgery underwent fMRI on a 3.0-T MR scanner. Brain activity was measured while viewing erotic male and female nude pictures. The average level of free T in the FtM transsexuals was in the normal range of heterosexual men. The brain areas with predominant activities during viewing female nude pictures in contrast to male pictures included the hippocampus, parahippocampal gyrus, anterior cingulate gyrus, putamen, amygdala, hypothalamus, and insula (p < 0.005). The free T levels were positively correlated with the BOLD signal changes in the parahippocampal gyrus (Spearman's rho = 0.91, p < 0.001), hippocampus (rho = 0.90, p < 0.001), insula (rho = 0.68, p < 0.05), putamen (rho = 0.66, p < 0.05), and amygdala (rho = 0.64, p < 0.05). Compared to FtM transsexuals with deficient level of free T, the FtM transsexuals with normal range of free T showed significantly higher activities in the p...Continue Reading

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Citations

Jan 27, 2019·International Journal of Impotence Research·Gwang-Won KimGwang-Woo Jeong
Nov 24, 2020·The Journal of Sexual Medicine·Sven C MuellerGuy T'Sjoen
Oct 3, 2020·Journal of the American College of Radiology : JACR·Jasper KennedyKristin K Porter
May 22, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Georg S KranzRupert Lanzenberger

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