Neural activation during experimental allodynia: a functional magnetic resonance imaging study

The European Journal of Neuroscience
Christian MaihöfnerHermann O Handwerker

Abstract

Abstract Pain induced by gentle stroking, i.e. dynamic-mechanical allodynia, is one of the most distressing symptoms of neuropathic pain. The underlying neuronal pathways are still a matter of debate. Here, we investigated the cortical activations associated with dynamic-mechanical allodynia in an experimental human pain model by functional magnetic resonance imaging (fMRI). Large and stable areas of brush-evoked allodynia were induced in 11 healthy subjects by topical capsaicin (2.5%, 30 min) application following local heating (45 degrees C for 5 min), thus combining both physical and chemical sensitization. During the fMRI experiments, allodynia was rekindled by local heat application (40 degrees C for 5 min) immediately before the allodynia testing. Brushing the untreated forearm (control condition) led to activations of the contralateral primary somatosensory cortex (S1), contralateral parietal association cortex (PA), bilateral secondary somatosensory cortices (S2) and insula (contralateral). Brushing the allodynic skin was painful and the cortical responses were partially overlapping with those induced by the nonpainful brush stimulation. Additionally, the contralateral inferior frontal cortex (IFC) and the ipsilateral i...Continue Reading

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Citations

Jun 25, 2008·Experimental Brain Research·Helena Backlund WaslingHåkan Olausson
Nov 29, 2011·Experimental Brain Research·Peggy J Planetta, Philip Servos
Mar 5, 2011·Journal of Neural Transmission·Stefan LanzChristian Maihöfner
Feb 15, 2005·Magnetic Resonance Imaging·Carlo Adolfo PorroPatrizia Baraldi
Jan 9, 2007·Cerebral Cortex·Ilaria BufalariSalvatore Maria Aglioti
Jun 7, 2008·Cerebral Cortex·Barry L WhitselMark Tommerdahl
Jan 15, 2008·La Presse médicale·Luis Garcia-Larrea, Michel Magnin
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·G D IannettiI Tracey
Mar 19, 2013·The Journal of Pain : Official Journal of the American Pain Society·Jennifer KornelsenBoguslaw Tomanek
May 6, 2008·The Journal of Pain : Official Journal of the American Pain Society·Heidrun H KrämerChristian Maihöfner
Mar 7, 2006·European Journal of Pain : EJP·Andreas HessKay Brune
Jan 15, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Christian Maihöfner, Frank Seifert
Mar 24, 2006·The European Journal of Neuroscience·Christian MaihöfnerHermann Otto Handwerker
Mar 15, 2011·European Journal of Pain : EJP·Kay-Wee PohWei-Yi Ong
Dec 2, 2011·Human Brain Mapping·Emma G Duerden, Marie-Claire Albanese
Jan 19, 2010·European Journal of Pain : EJP·V Tronnier, F Birklein
Aug 23, 2005·NeuroImage·Christian Maihöfner, Hermann O Handwerker
Oct 4, 2006·Neuron·James N Campbell, Richard A Meyer
Jul 12, 2011·Neuroscience Letters·Linda C LundbladHelena Backlund Wasling
Jun 28, 2008·NeuroImage·Tanja StammlerChristian Maihöfner
Nov 15, 2007·NeuroImage·David M NiddamJen-Chuen Hsieh
Mar 16, 2007·NeuroImage·Frank Seifert, Christian Maihöfner
Jul 16, 2014·Pain·Christopher T McNabbPerry N Fuchs
Sep 12, 2013·Pain·Luis Garcia-Larrea, Roland Peyron
Apr 7, 2009·European Journal of Pain : EJP·Christian MaihöfnerMartin Kaltenhäuser
Aug 12, 2016·Frontiers in Human Neuroscience·Antonino NaroAngelo Quartarone
Jan 14, 2010·Anesthesiology·Esther M Pogatzki-ZahnBettina Pfleiderer
Aug 24, 2007·Journal of Neurophysiology·Lina HerdeHermann O Handwerker

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