PMID: 9437667Jan 23, 1998Paper

Neural and astroglial effects of a chronic parachlorophenylalanine-induced serotonin synthesis inhibition

Molecular and Chemical Neuropathology
Patricia TagliaferroAlicia Brusco

Abstract

Serotonin (5HT) is one of the classical neurotransmitters expressed earlier in the embryonic rat brain, and it was proposed as a developmental signal in the central nervous system. In the adult brain, 5HT seems to be involved in neuronal plasticity. It was postulated that S-100 protein, a glial neurotrophic factor, could be modulated by 5HT probably through the glial 5HT1A receptors. In a model of chronic inhibition of endogenous 5HT synthesis produced by the daily administration of parachlorophenylalanine (PCPA) for 2 wk, we have studied by immunohistochemical methods and digital morphometric analysis the expression of two proteins present in rat brain astrocytes: glial fibrillary acidic protein (GFAP) and S-100 protein. The effectiveness of the PCPA treatment was tested by the use of specific anti-5HT antibodies that showed absence of 5HT fibers in 5HT innervation areas like frontal cortex and hippocampus. Different effects of PCPA treatment on serotoninergic raphe nuclei were observed: dorsal raphe nucleus (DRN) seemed to be more sensitive to the PCPA's action than ventral raphe nucleus (VRN). In DRN and in the two 5HT innervation areas studied, glial cells responded to the 5HT depletion induced by PCPA showing astrocytes wi...Continue Reading

References

Jan 1, 1978·Developmental Neuroscience·J M Lauder, H Krebs
Jan 1, 1991·Glia·A Selvín-TestaJ Pecci Saavedra
Feb 1, 1990·Brain Research. Developmental Brain Research·G Le PrinceM Tardy
Jan 1, 1987·Neuroscience·E C Azmitia, P M Whitaker-Azmitia
Feb 18, 1985·Brain Research·A J Mathewson, M Berry
Aug 1, 1970·Journal of Neurochemistry·E M GálS A Millard
Apr 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A BruscoJ Pecci Saavedra
Nov 1, 1983·Journal of Neurochemistry·P M WhitakerR Morin
Nov 1, 1981·Journal of Neurochemistry·L Hertz, H Tamir
May 1, 1995·The International Journal of Neuroscience·A BruscoJ P Saavedra
Jan 14, 1995·Brain Research. Developmental Brain Research·F C ZhouS Bledsoe
Oct 1, 1994·Brain Research. Molecular Brain Research·H HardinM Didier-Bazes
Mar 7, 1994·Brain Research·C FagesM Tardy
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·P JäkäläP J Riekkinen
Apr 1, 1997·Molecular and Chemical Neuropathology·A BruscoR Duffard

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Citations

Jul 10, 2002·Annals of the New York Academy of Sciences·Alberto Javier RamosAlicia Brusco
Nov 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Guo-Jen Huang, Joe Herbert
May 12, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ricardo LlorenteMaría-Paz Viveros
Feb 24, 2006·Journal of Neuroscience Research·Virginia G BarrosMarta C Antonelli
Jul 10, 2002·Annals of the New York Academy of Sciences·Patricia TagliaferroAlicia Brusco
Jan 4, 2021·Experimental Gerontology·Antonio GarridoMeritxell López-Gallardo
Jun 6, 2006·Journal of Psychiatric Research·Katja SchlichtBrigitta Bondy

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